With a plethora of players returning from international duty, the Fit or Miss list is a little longer than usual, as players who were deemed unfit to participate in World Cup qualifiers may be ready to play by the time Premier League games start up again.
With that said, here's what we're seeing so far:
Manchester United vs. Crystal Palace
Out: Jack Hunt is out after breaking his ankle this week. Glenn Murray is still out and expected to return sometime in December. Jonny Williams damaged ligaments in his ankle while playing for Wales and will miss up to three months.
Not Expected to Play: Wayne Rooney suffered a gash on his head during training with the England squad and was unable to play in two World Cup qualifiers. Phil Jones could miss out after suffering an ankle injury in last week's match against Liverpool, which forced him to miss both of England's World Cup qualifiers. Rafael continues to rehab his way back from a hamstring injury but doesn't appear to have returned to full training yet. Darren Fletcher continues to battle a chronic bowel illness, although he was named to United's 25-man squad for the season. Jerome Thomas still seems to be on the mend from his ankle injury.
Aston Villa vs. Newcastle United
Out: Ryan Taylor remains sidelined after undergoing ACL surgery in April.
Not Expected to Play: Massadio Haidara suffered a setback in his recovery from a knee injury in training.
Fulham vs. West Bromwich Albion
Out: Matej Vydra remains out with a hamstring injury. Ben Foster remains out with a stress fracture in his foot.
Not Expected to Play: James Morrison has not recovered from a groin injury he sustained prior to the international break. Zoltan Gera (knee) is close to a return but it doesn't appear like he'll be ready by this weekend. Kieren Richardson is still battling his way back from a hamstring injury.
Expected to Play: Maarten Stekelenburg appears ready to return from his shoulder injury, although it's not guaranteed yet.
Hull City vs. Cardiff City
Not Expected to Play: Steven Caulker missed both of England's World Cup qualifiers after injuring his ankle in training.
Expected to Play: Allan McGregor should be good to go despite suffering a slight groin injury while on international duty. David Marshall left Scotland's qualifier against Macedonia on Tuesday in the second half but could be fit in time for Saturday. Andreas Cornelius should be good to go after missing Cardiff's last Premier League match with an ankle injury.
Stoke City vs. Manchester City
Out: Vincent Kompany has not recovered as quickly from his thigh injury and he could be out until October. Martin Demichelis is out for at least another five weeks after suffering a knee ligament injury. Friday update: Gael Clichy is out after picking up a knock midweek while playing for France.
Not Expected to Play: David Silva pulled out of Spain's friendly against Chile on Tuesday with a thigh injury and returned to Manchester for treatment this week. He could be a late-decision based on a pre-match fitness test. Glenn Whelan picked up a hamstring injury during last Friday's World Cup qualifier against Sweden. Micah Richards remains sidelined despite the plethora of injuries to the City back four.
Sunderland vs. Arsenal
Out: Lukas Podolski (hamstring) is not expected to return for another three months. Alex Oxlade-Chamberlain (knee) isn't expected back until the end of October, at the earliest. John O'Shea is out after receiving a red card against Crystal Palace on August 31.
Not Expected to Play: Yaya Sanogo picked up a back injury while on U-21 international duty. Tomas Rosicky picked up a thigh injury Tuesday against Italy. Mikel Arteta is still working his way back from a quad injury. Craig Gardner is sidelined with an groin injury. Phillip Bardsley has not been publicly confirmed back to the squad following his indefinite suspension earlier this season for mocking the club.
Expected to Play: Thomas Vermaelen has returned to full training and could return this weekend. Theo Walcott picked up a slight knock in Tuesday's World Cup qualifier against Ukraine, but should be good to go. Jozy Altidore is expected to return despite missing two World Cup qualifiers for the United States this week. Lee Cattermole could make his season debut after returning from a knee injury.
Tottenham Hotspur vs. Norwich City
Out: Etienne Capoue is out for another two-to-three weeks after suffering an ankle injury against Arsenal on September 1.
Not Expected to Play: Aaron Lennon continues to experience pain in his foot and with the depth at midfield for Spurs, he can afford to wait until fully healthy.
Expected to Play: Gary Hooper has returned to training and will take a prematch fitness test to determine whether he plays or not.
Everton vs. Chelsea
Out: Romelu Lukaku is forced to sit this one out as part of his loan agreement between the two clubs.
Not Expected to Play: Darron Gibson and Antolin Alcaraz have returned to training but have not regained match fitness yet.
Expected to Play: Eden Hazard has been deemed fit to play after leaving training with the Belgium squad earlier this week. Seamus Coleman and James McCarthy both picked up knocks but are expected to play.
Southampton vs. West Ham
Out: Andy Carroll suffered a new foot injury and is now out indefinitely. Joe Cole is expected to miss five more weeks with a torn hamstring.
Not Expected to Play: Stewart Downing is out for at least another two weeks with a leg injury sustained on August 31 against Stoke.
Swansea City vs. Liverpool
Out: Neil Taylor remains sidelined with a thigh injury and could miss the next few weeks. Glen Johnson, who missed two World Cup qualifiers with England, is out with an ankle injury. Luis Suarez remains suspended for biting Branislav Ivanovic last season. Sebastian Coates is out after tearing his ACL in August.
Not Expected to Play: Nathan Dyer is still dealing with a hamstring issue but there's a chance he could return. Aly Cissokho remains sidelined with an ankle injury sustained at the end of August. Joe Allen could be fit, although it's unclear if he'll be well enough to play.
Expected to Play: Daniel Sturridge (thigh) missed both of England's World Cup qualifiers over the international break but is expected to be fit by Monday. Kolo Toure is expected to be fit after recovering from a groin injury.