Robin van Persie (knee), Christian Benteke (Achilles), Jay Rodriguez (knee), Eden Hazard (thigh) and Yaya Toure (groin) are all out this week, which means we could see a number of goals from unlikely boots.
As a reminder, the players mentioned below are only a few of those that are battling injuries, or getting ready to return. If you're looking for a full list, you can find that here. And if it's a specific player you're looking for, just search for them above and all of their injury information will be listed on their player page.
Here's everything else we're seeing ahead of Gameweek 35:
Saturday, April 19
Tottenham vs. Fulham
Mousa Dembele (hip) is in contention to play, while Michael Dawson and Roberto Soldado have both returned to training following their respective hamstring injuries. However, Jan Vertonghen (ankle) and Sandro are likely a week away, with Kyle Walker (pelvis) and Etienne Capoue (ankle) out for a longer period. Kostas Mitroglu remains out with a knee injury, while Lewis Holtby is ineligible to play against his parent club.
Aston Villa vs. Southampton
Leandro Bacuna is expected to return from the hamstring injury that kept him out last weekend, which is good news for a Villa side looking for goals after Christian Benteke suffered a ruptured Achilles a few weeks ago. Artur Boruc has been deemed fit to return from his back injury after missing the last two games. However, Gaston Ramirez will miss out after injuring his ankle last weekend.
Cardiff City vs. Stoke City
Kenwyne Jones is suffering from bruised kidneys and could miss out, while Craig Noone (abdomen) is still a few weeks away. Charlie Adam is expected to feature after having surgery Monday on his broken nose, while Oussama Assaidi could return from his knee injury next weekend.
Newcastle vs. Swansea City
Loic Remy (calf) and Mathieu Debuchy (groin) look set to return, although Moussa Sissoko is not quite ready yet, having just begun running again. Hatem Ben Arfa could also miss out after picking up a knock last weekend, and Davide Santon was ruled out for the rest of the season with a hamstring injury. Michu will be given a late fitness test for his ankle, but he is not expected to pass, and Chico Flores will miss out due to a red card ban.
West Ham vs. Crystal Palace
Kevin Nolan (hamstring) was unable to pass a late fitness test ahead of Tuesday's match against Arsenal, but he is expected to return Saturday. Kagisho Dikgacoi was unable to pass a late fitness test ahead of Wednesday's match against Everton.
Chelsea vs. Sunderland
Phil Bardsley will miss out due to a card ban, while Ki Sung-Yueng is expected to miss a few weeks with knee tendonitis. Eden Hazard remains sidelined with a calf injury and has no clear return date.
Sunday, April 20
Norwich City vs. Liverpool
Daniel Sturridge faces a late fitness test due to a hamstring injury, while Jordan Henderson misses out due to a red card ban. Elliott Bennett will need another week before he returns from his knee injury.
Hull City vs. Arsenal
Hull have a number of long-term injuries, including Allan McGregor (kidney), Robbie Brady (groin), Paul McShane (ankle), and Joe Dudgeon (knee). Kieran Gibbs (ankle) looks likely to sit out, although Arsenal will welcome back Mesut Ozil, who has not played since injuring his hamstring against Bayern Munich in the Champions League back on March 11. Jack Wilshere's ankle injury will likely keep him out until May.
Everton vs. Manchester United
Phil Jagiela is expected to be fit enough for the bench after missing time recently with a hamstring injury, although Steven Pienaar remains out with his knee injury. Wayne Rooney (toe) made a surprise return to training Thursday and has been deemed fit to play. Marouane Fellaini (calf) has also returned to training and he looks likely to face his former club. Defenders Rafael (thigh) and Jonny Evans (calf) also have a shot at returning.
Monday, April 21
Manchester City vs. West Brom
David Silva was held out of Wednesday's match against Sunderland due to an ankle injury he's been dealing with for the last two games, but he is expected back. Yaya Toure will miss out with a groin injury, although he may be able to return the following weekend. Jonas Olsson could miss out due to an Achilles injury, while James Morrison could miss out with an ankle injury.