Rams vs 49ers Odds, Lines, Spreads & Totals 2026

49ers
Rams
Thursday September 10, 2026 at 8:35 PM ET
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49ers Injury Report
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49ers Lineup
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49ers News
#2 WR
Deebo Samuel: Successful 49ers return in win
Sep 10th
Samuel brought in six of seven targets for 48 yards and a touchdown, rushed once for 12 yards and returned two kickoffs for 74 yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia.
#1 TE
George Kittle: Pair of catches in Week 1
Sep 10th
Kittle brought in two of five targets for 12 yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia.
#2 RB
Kaelon Black: Stands out in regular-season debut
Sep 10th
Black rushed 14 times for 65 yards and brought in his only target for five yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia.
#1 MLB
Fred Warner: Racks up 11 stops in season-opening win
Sep 10th
Warner finished the 49ers' 27-7 Week 1 win against the Rams with 11 tackles (five solo) and a defensed pass.
#1 WR
Mike Evans: Clicks quickly with Purdy
Sep 10th
Evans secured six of seven targets for 49 yards and a touchdown during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia.
#1 K
Eddy Pineiro: Goes 2-for-3 on FG tries Thursday
Sep 10th
Pineiro converted two of his three field-goal attempts and all three of his extra-point tries in the 49ers' season-opening 27-7 win against the Rams.
#1 QB
Brock Purdy: Three-TD effort to open season
Sep 10th
Purdy completed 25 of 34 passes for 205 yards with three touchdowns and one interception while adding five rushes for 29 yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia.
#4 TE
Jake Tonges: Injury believed to be serious
Sep 10th
Coach Kyle Shanahan said after Thursday night's win over the Rams that Tonges' knee injury "does not look good," Vic Tafur of The Athletic reports.
#8 WR
De'Zhaun Stribling: Avoids Achilles injury
Sep 10th
Stribling (ankle) avoided an Achilles injury Thursday against the Rams after initial tests revealed his Achilles is intact, James Palmer of The Athletic reports.
#1 RB
Christian McCaffrey: Efficient with modest workload
Sep 10th
McCaffrey rushed 10 times for 68 yards and brought in five of eight targets for 20 yards during the 49ers' 27-7 Week 1 win over the Rams in Melbourne, Australia.
#2 RCB
Ephesians Prysock: Won't make debut Thursday
Sep 10th
Prysock (coach's decision) is officially inactive for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
#2 MLB
Tatum Bethune: Healthy scratch Thursday
Sep 10th
Bethune (coach's decision) is officially inactive for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
#5 WR
Jordan Watkins: Won't play Thursday
Sep 10th
Watkins (coach's decision) is officially inactive for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
#3 RB
Jordan James: Inactive Thursday
Sep 10th
James (coach's decision) is officially inactive for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
#3 DT2
Alfred Collins: Officially lands on IR
Sep 10th
San Francisco placed Collins (knee) on injured reserve Thursday.
#2 SLB
Luke Gifford: Set for TNF in Australia
Sep 9th
Gifford (hamstring) does not have an injury designation ahead of Thursday's contest against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
#1 DT2
Gracen Halton: Ready to rock
Sep 9th
Halton (ankle) does not have an injury designation ahead of Thursday's contest against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
#2 LDE
Romello Height: Ready for Thursday
Sep 9th
Height (ankle) does not have an injury designation ahead of Thursday's contest against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
#1 LCB
Renardo Green: Set for TNF in Australia
Sep 9th
Green (hamstring) does not have an injury designation ahead of Thursday's contest against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
#1 WLB
Dre Greenlaw: Set to suit up
Sep 9th
Greenlaw (Achilles) does not have an injury designation ahead of Thursday's contest against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
#1 FB
Kyle Juszczyk: Cleared to play in opener
Sep 9th
Juszczyk (finger) does not have an injury designation for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
#1 RDE
Nick Bosa: No injury designation for opener
Sep 9th
Bosa (knee) does not have an injury designation for Thursday's game against the Rams, Matt Maiocco of NBC Sports Bay Area reports.
#2 LCB
Jack Jones: Cleared Wednesday
Sep 9th
Jones (hand) was a full participant in Wednesday's practice.
#2 LT
Vederian Lowe: Full practice Tuesday
Sep 8th
Lowe (ankle) did not appear on the 49ers' injury report Tuesday, Matt Maiocco of NBC Sports Bay Area reports.
#1 RG
Dominick Puni: Good to go for Week 1
Sep 8th
Puni (concussion) was not listed on the 49ers' injury report Tuesday, Matt Maiocco of NBC Sports Bay Area reports.
#1 LDE
Keion White: Healthy ahead of Week 1
Sep 8th
White (groin) was not listed on the 49ers' injury report Tuesday, Matt Maiocco of NBC Sports Bay Area reports.
#2 SS
Malik Mustapha: Ready to go for Week 1
Sep 8th
Mustapha (hamstring) did not appear on the 49ers' injury report Tuesday, Matt Maiocco of NBC Sports Bay Area reports.
#3 QB
Kurtis Rourke: Full practice Tuesday
Sep 8th
Rourke (ribs) did not appear on the 49ers' injury report Tuesday, Matt Maiocco of NBC Sports Bay Area reports.
#4 WR
Jacob Cowing: Healthy ahead of Week 1
Sep 8th
Cowing (groin) did not appear on the 49ers' injury report Tuesday, Matt Maiocco of NBC Sports Bay Area reports.
#1 SCB
Upton Stout: Healthy ahead of Week 1
Sep 8th
Stout (hip) was a full participant at the 49ers' practice Tuesday, Matt Maiocco of NBC Sports Bay Area reports.
#4 LDE
Sam Okuayinonu: Will undergo foot surgery
Sep 7th
San Francisco head coach Kyle Shanahan said Monday that Okuayinonu broke his foot in practice last week and is set to have surgery, Matt Barrows of The Athletic reports.
#3 MLB
Nick Martin: Lands on IR
Sep 1st
The 49ers placed Martin (hamstring) on injured reserve Tuesday, Aaron Wilson of KPRC 2 Houston reports.
#3 RCB
Nate Hobbs: Placed on injured reserve
Sep 1st
The 49ers placed Hobbs (groin) on injured reserve Tuesday, Aaron Wilson of KPRC 2 Houston reports.
#3 TE
Brayden Willis: Practices Tuesday
Sep 1st
Willis (concussion) participated in Tuesday's practice, Nick Wagoner of ESPN.com reports.
#3 LG
Nick Zakelj: Set to miss entire 2026 season on IR
Aug 31st
Zakelj (undisclosed) was placed on the 49ers' injured reserve Sunday.
#3 C
Brett Toth: Placed on season-ending IR
Aug 31st
The 49ers placed Toth (concussion) on injured reserve Sunday.
#4 LT
Austen Pleasants: Starting season on injured reserve
Aug 31st
The 49ers placed Pleasants (knee) on injured reserve with a designation to return Sunday.
#3 RDE
Mykel Williams: Moved to reserve/PUP list
Aug 31st
Williams (knee) was moved to the reserve/PUP list by the 49ers on Sunday.
#6 WR
Christian Kirk: Placed on IR, designated to return
Aug 30th
Kirk (calf) was placed on injured reserve by the 49ers on Sunday with a designation to return.
#2 C
Jarrett Patterson: Traded to 49ers
Aug 30th
Patterson was traded to the 49ers from the Texans on Sunday, Tom Pelissero of Netflix reports.
#4 RB
Isaac Guerendo: Lands on reserve/PUP list
Aug 30th
Guerendo (pectoral) was placed on the reserve/PUP list Sunday, Jeremy Fowler of ESPN reports.
#2 QB
Mac Jones: Quick appearance in preseason finale
Aug 28th
Jones completed one of his five pass attempts for seven yards in Thursday night's preseason finale against the Raiders.
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Rams News
#2 RB
Blake Corum: Impressive with limited touches
Sep 10th
Corum rushed 10 times for 54 yards and wasn't targeted during the Rams' 27-7 Week 1 loss to the 49ers in Melbourne, Australia.
#2 WR
Davante Adams: Held in check in Week 1 loss
Sep 10th
Adams secured three of six targets for 26 yards during the Rams' 27-7 Week 1 loss to the 49ers in Melbourne, Australia.
#1 SCB
Quentin Lake: Picks off Purdy in season opener
Sep 10th
Lake recorded 10 tackles (seven solo) and three defensed passes, including an interception, in the Rams' Week 1 loss to the 49ers.
#1 QB
Matthew Stafford: Disappointing performance to open season
Sep 10th
Stafford completed 15 of 25 passes for 155 yards with no touchdowns and one interception while rushing twice for minus-1 yard during the Rams' 27-7 Week 1 loss to the 49ers in Melbourne, Australia.
#1 K
Harrison Mevis: Has quiet season opener
Sep 10th
Mevis made his lone extra-point try and didn't attempt any field goals in the Rams' Week 1 loss to San Francisco.
#3 ROLB
Myles Garrett: Admits he's not 100 percent
Sep 10th
Garrett said after Thursday night's loss to the 49ers that his knee is not 100 percent healthy, Greg Beacham of the Associated Press reports.
#1 RB
Kyren Williams: Records TD in Week 1 loss
Sep 10th
Williams rushed 11 times for 41 yards and a touchdown and brought in all three targets for 24 yards during the Rams' 27-7 Week 1 loss to the 49ers in Melbourne, Australia.
#1 WR
Puka Nacua: Solid numbers in Week 1 loss
Sep 10th
Nacua brought in five of nine targets for 74 yards during the Rams' 27-7 Week 1 loss to the 49ers in Melbourne, Australia.
#3 TE
Davis Allen: Getting examined for possible concussion
Sep 10th
Allen is getting examined for a possible concussion and is questionable to return to Thursday's matchup with the 49ers.
#1 SS
Kam Curl: Questionable to return Thursday
Sep 10th
Curl (ankle) is questionable to return to Thursday's game against the 49ers, Gary Klein of the Los Angeles Times reports.
#4 TE
Max Klare: Healthy scratch to begin rookie campaign
Sep 10th
Klare (coach's decision) is inactive for Thursday's season-opener versus San Francisco in Melbourne, Australia, Nate Atkins of The Athletic reports.
#6 WR
CJ Daniels: Won't make NFL debut in Thursday's opener
Sep 10th
Daniels (coach's decision) is a healthy scratch for Thursday's matchup versus San Francisco in Melbourne, Australia, Nate Atkins of The Athletic reports.
#5 WR
Tutu Atwell: Inactive for season opener
Sep 10th
Atwell (coach's decision) is inactive for Thursday's tilt against the 49ers in Melbourne, Australia, Nate Atkins of The Athletic reports.
#3 QB
Ty Simpson: Opening season as emergency No. 3 QB
Sep 10th
Simpson is inactive as the Rams' emergency third quarterback for Thursday's matchup against San Francisco in Melbourne, Australia, Nate Atkins of The Athletic reports.
#2 QB
Stetson Bennett: Active as No. 2 QB on Thursday
Sep 10th
Bennett is set to work as the Rams' backup quarterback behind Matthew Stafford on Thursday versus San Francisco, Nate Atkins of The Athletic reports.
#1 LCB
Jaylen Watson: Cleared to face 49ers in Australia
Sep 10th
Watson (toe) was a full participant on Thursday's estimated injury report and doesn't carry an injury designation into Thursday night's game against the 49ers, Sarah Barshop of ESPN.com reports.
#1 LT
Alaric Jackson: Rested at practice
Sep 8th
Jackson (rest) did not participate at the Rams' practice Tuesday, Sarah Barshop of ESPN.com reports.
#2 RILB
Shaun Dolac: Healthy ahead of Week 1
Sep 8th
Dolac (knee) did not appear on the Rams' injury report Tuesday, Sarah Barshop of ESPN.com reports.
#1 LDE
Kobie Turner: Full practice Tuesday
Sep 8th
Turner (undisclosed) was a full participant at the Rams' practice Tuesday, Sarah Barshop of ESPN.com reports.
#5 TE
Terrance Ferguson: Sheds injury tag
Sep 8th
Ferguson (soreness) was not listed on the injury report the Rams released Tuesday, according to Sarah Barshop of ESPN.com.
#1 RDE
Aaron Donald: Not playing in opener in Australia
Sep 8th
Head coach Sean McVay said that Donald won't travel to Melbourne, Australia and will be inactive Thursday for the Rams' season opener versus the 49ers, Stu Jackson of the team's official site reports.
#2 RG
Justin Dedich: Moves to IR
Aug 31st
Dedich (undisclosed) was put on injured reserve with a designation to return by the Rams on Sunday, Cameron DaSilva of USA Today reports.
#2 RT
Keagen Trost: Placed on IR
Aug 31st
Trost (hamstring) was placed on injured reserve with a designation to return by the Rams on Sunday, Cameron DaSilva of USA Today reports.
#4 QB
Matthew Caldwell: Lands on IR
Aug 29th
The Rams placed Caldwell (undisclosed) on injured reserve Saturday, Aaron Wilson of KPRC 2 Houston reports.
#3 RB
Dean Connors: Shoulders heavy workload in win
Aug 27th
Connors rushed 18 times for 69 yards and brought in all three targets for 24 yards and a touchdown in the Rams' 20-18 preseason win over the Chargers on Thursday.