This article is part of our Game Spotlight series.
San Francisco vs. Los Angeles Rams, 4:25
Open: 52.5 O/U, LAR -11
Live: 52 O/U, LAR -9.5
Cooper Kupp (knee) is out, making the projections for Brandin Cooks and Robert Woods that much stronger. The Rams offense is generally matchup-proof and while Kupp's absence might present some challenges, the presumption should be the show will proceed as scheduled, especially against a relatively vulnerable defense like San Francisco's. If we assume Jared Goff produces as he normally does, then Cooks and Woods should meet and exceed their usual standards, especially with the 49ers conceding roughly 40 pass attempts per game. When the Rams go three-wide I would guess Woods moves into the slot, though Cooks can certainly handle that task, too. Josh Reynolds should be the second outside receiver when the Rams go three-wide, which should occur something like 40 times or more. Reynold is a lanky receiver with a strong jumpball game, but his tasks should generally be limited to outside and vertical routes. I can't see him doing much over the middle, but he should present real GPP utility in DFS as long as he sees at least five targets.
I don't see the need to mention much about Todd Gurley. He's an incredibly strong play.
The 49ers backfield is more worthy of speculation, though. Matt Breida unexpectedly played through his ankle and shoulder troubles against Green Bay on Monday, and he mostly looked like himself in the process, running for 61 yards and a touchdown on