NFL Week 2 Odds: Biggest Line Moves, Betting Splits and Key Injuries
The goal of this article is to look at the key line moves for the week and what they mean in terms of betting. Key numbers in the NFL to watch for are 3, 7, 6, 14, and 10. When a line crosses through one of these, it warrants significant attention.
On the totals side, the key numbers are 41, 43, 37, 44, 51, 33, 47.
A quarterback is the only position that can significantly move an NFL point spread, and a top-tier QB can be worth up to seven or more points. For all other positions, the impact is minimal and usually less than a single point, unless multiple players on the same unit are injured. When a unit has multiple starters out, it is often overlooked in the handicapping world. OL, DL, secondary, and WR are the units that are impacted the most.
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NFL Week 2 Odds
Week 2 NFL Lines (odds via BetMGM)
* Home team in bold
| Favorite | Underdog | Opening Line | Current Line | Line Movement | Opening O/U | Current O/U | O/U Movement |
| Bills | Lions | -3.0 | -4.5 | BUF +1.5 | 52.5 | 53.5 | 1.0 |
| Ravens | Saints | -7.5 | -8.5 | BAL +1.0 | 46.5 | 47.5 | 1.0 |
| Packers | Jets | -4.5 | -4.0 | NYJ +0.5 | 43.5 | 44.5 | 1.0 |
| Bears | Vikings | -3.5 | -5.5 | CHI +2.0 | 45.5 | 49.5 | 4.0 |
| Patriots | Steelers | -4.5 | -5.0 | NE +0.5 | 43.5 | 42.0 | -1.5 |
| Texans | Bengals | -2.5 | -3.0 | HOU +0.5 | 46.5 | 47.0 | 0.5 |
| Eagles | Titans | -7.0 | -7.0 | 0.0 | 40.0 | 39.5 | -0.5 |
| Buccaneers | Browns | -6.5 | -8.5 | TB +2.0 | 42.5 | 41.0 | -1.5 |
| Panthers | Falcons | 1.5 | -1.5 | CAR +3.0 | 43.5 | 43.5 | 0.0 |
| Broncos | Jaguars | -3.0 | -2.5 | JAX +0.5 | 43.5 | 44.5 | 1.0 |
| Chargers | Raiders | -8.5 | -7.0 | LV +1.5 | 42.5 | 44.0 | 1.5 |
| Cowboys | Commanders | -4.5 | -3.5 | WAS +1.0 | 51.5 | 50.5 | -1.0 |
| 49ers | Dolphins | -10.5 | -12.5 | SF +2.0 | 46.5 | 45.5 | -1.0 |
| Seahawks | Cardinals | -10.0 | -4.5 | ARI +5.5 | 44.5 | 41.0 | -3.5 |
| Chiefs | Colts | -5.5 | -6.5 | KC +1.0 | 47.5 | 48.0 | 0.5 |
| Rams | Giants | -8.5 | -7.0 | NYG +1.5 | 47.5 | 48.5 | 1.0 |
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NFL Week 2 Line Movement
NFL Week 2 Line Moves, Betting Splits and Injury Report
Week 2 is one of the most volatile points of the NFL betting season. Sportsbooks finally have regular-season results to incorporate, while bettors must determine how much one game should change their preseason expectations.
Several spreads and totals have already moved substantially from last week's lookahead numbers. Injuries are also influencing the market, while early DraftKings betting splits reveal several significant gaps between ticket percentages and money wagered.
Here is the Week 2 market report, with opening numbers, current lines, betting splits, injuries and betting takeaways.
Lions at Bills: Buffalo Moves Through Three
Opening: Bills -3 | Total 51.5
Current: Bills -4.5 | Total 53.5
DK Split: Bills 64% bets, 91% money
Buffalo has moved through the key number of three while the total has climbed two points. Week 1 reinforced Buffalo's status as a contender, and larger early wagers have strongly favored the Bills.
Betting Takeaway: Anyone backing Buffalo early received considerable closing-line value. The spread and total movement show the market upgrading expectations for Buffalo's offense.
Panthers at Falcons: Carolina Flips to Favorite
Opening: Falcons -1.5 | Total 44.5
Current: Panthers -1.5 | Total 44.5
DK Split: Panthers 86% bets, 83% money
Atlanta entered Week 1 with quarterback uncertainty involving Tua Tagovailoa, Michael Penix Jr. and Cooper Rush. Carolina's disastrous defensive opener didn't prevent bettors from pushing this game through pick'em.
Betting Takeaway: A favorite flipping sides is more significant than the raw three-point move. Atlanta's quarterback situation remains the primary variable.
Vikings at Bears: Murray Injury Drives Chicago Higher
Opening: Bears -3 | Total 48.5
Current: Bears -5.5 | Total 49.5
DK Split: Bears 64% bets, 83% money
Kyler Murray suffered a concussion against Green Bay, putting Carson Wentz in position to start. Chicago also received a Week 1 power-rating boost after its offensive explosion.
Betting Takeaway: The market has already made a substantial quarterback adjustment. Any Murray update could produce another move.
Eagles at Titans: Philadelphia Reaches Seven
Opening: Eagles below -7 | Total 41
Current: Eagles -7 | Total 39.5
DK Split: Eagles 86% bets, 95% money
Tennessee's poor opener pushed Philadelphia to the key number of seven. The Eagles are also receiving some of the most one-sided early support on the board.
Betting Takeaway: Seven is the number that matters. The simultaneous decline in the total increases the relative importance of each point on the spread.
Steelers at Patriots: New England Moves a Point
Opening: Patriots -4.5 | Total 43.5
Current: Patriots -5.5 | Total 42.5
DK Split: Patriots 43% bets, 76% money
New England has moved a full point despite receiving fewer spread tickets than Pittsburgh. The Patriots are attracting substantially larger wagers.
Betting Takeaway: This is one of the more interesting reverse ticket-money splits. Pittsburgh has the public ticket advantage, but New England has three-quarters of the handle.
Packers at Jets: New York Attracts the Money
Opening: Packers -5.5 | Total 43.5
Current: Packers -4.5 | Total 44.5
DK Split: Jets 57% bets, 90% money
Green Bay's collapse against Minnesota and New York's surprising opening victory cut the Packers' price. The splits reinforce the movement, with the Jets attracting an overwhelming percentage of spread money.
Betting Takeaway: This isn't merely public reaction to Week 1. The difference between New York's ticket count and handle makes this one of the week's most notable betting splits.
Browns at Buccaneers: Cleveland Downgraded
Opening: Buccaneers around -8 | Total 40.5
Current: Buccaneers -8.5 | Total 40.5
DK Split: Buccaneers 82% bets, 91% money
Cleveland's poor Week 1 performance generated an immediate power-rating downgrade. Tampa Bay has attracted strong support from both tickets and money.
Betting Takeaway: Unlike several other games, there's little disagreement between ticket count and handle. The market is firmly positioned toward Tampa Bay.
Saints at Ravens: Baltimore Price Climbs
Opening: Ravens -7.5 | Total 46.5
Current: Ravens -8.5 | Total 46.5
DK Split: Ravens 53% bets, 73% money
Baltimore's 41-23 opener strengthened its market rating, but Zay Flowers' hamstring injury bears watching. Rookie receiver Ja'Kobi Lane also suffered a fractured wrist.
Betting Takeaway: Larger wagers favor Baltimore despite a nearly even ticket count. Flowers' availability could influence the next move.
Bengals at Texans: Houston Money Shows Up
Opening: Texans -2.5 | Total 47.5
Current: Texans -3 | Total 46.5
DK Split: Texans 38% bets, 83% money
The spread has reached the key number of three despite Cincinnati receiving most tickets. Houston has attracted 83 percent of the money on only 38 percent of wagers.
Betting Takeaway: This is arguably the strongest ticket-money divergence of Week 2. The market movement and handle are pointing in the same direction despite public support for Cincinnati.
Raiders at Chargers: Los Angeles Drops to Seven
Opening: Chargers -9/-9.5 | Total 45.5
Current: Chargers -7 | Total 43.5
DK Split: Raiders 63% bets, 60% money
Los Angeles' Week 1 loss produced one of the week's biggest downward adjustments. Ladd McConkey is also day-to-day with a rib injury, while Raiders tight end Brock Bowers is recovering from a meniscus procedure.
Betting Takeaway: Falling through eight and toward seven represents a major repricing. Injury updates could determine whether seven holds.
Jaguars at Broncos: Denver Approaches Three
Opening: Broncos around -2 | Total around 44
Current: Broncos -2.5 | Total 44.5
DK Split: Jaguars 67% bets, 54% money
This market has remained relatively stable compared to the larger Week 2 moves. Jacksonville is attracting more tickets, but the money split is much closer.
Betting Takeaway: Three is the number to watch. Denver reaching -3 would be considerably more meaningful than the current half-point adjustment.
Commanders at Cowboys: Dallas Money, Washington Tickets
Opening: Cowboys around -4.5 | Total 50
Current: Cowboys -3.5 | Total 50.5
DK Split: Cowboys 49% bets, 73% money
Dallas has moved closer to three following its Week 1 loss. Washington is receiving slightly more tickets, but nearly three-quarters of the spread money is backing Dallas.
Betting Takeaway: The spread and betting splits are sending different signals. A move to Dallas -3 would create a significantly different market.
Seahawks at Cardinals: Darnold Injury Reshapes Market
Opening: Seahawks significantly higher | Total 42.5
Current: Seahawks -4.5 | Total 41.5
DK Split: Seahawks 67% bets, 71% money
Sam Darnold's injury combined with Arizona's Week 1 upset produced one of the largest adjustments on the board. Seattle is still attracting most of the action at the reduced price.
Betting Takeaway: The quarterback downgrade has already been incorporated. The reduced Seattle number is now drawing support.
Dolphins at 49ers: San Francisco Approaches 14
Opening: 49ers -10/-10.5 | Total 46.5
Current: 49ers -13.5 | Total 45.5
DK Split: 49ers 88% bets, 90% money
San Francisco's dominant Week 1 performance and Miami's disappointing opener produced a three-point-plus adjustment.
Betting Takeaway: This is one of Week 2's biggest overreaction tests. San Francisco has crossed several numbers and is approaching the key threshold of 14.
Colts at Chiefs: Spread Holds Below Seven
Opening: Chiefs around -6.5 | Total around 47.5
Current: Chiefs -6.5 | Total 47.5
DK Split: Chiefs 59% bets, 72% money
Kansas City hasn't moved through seven despite attracting most spread bets and money. Interestingly, Indianapolis has attracted 75 percent of moneyline handle despite only nine percent of moneyline tickets.
Betting Takeaway: The stable spread is noteworthy. The unusual Colts moneyline split is the more interesting early market signal.
Giants at Rams: New York Pushes Rams to Seven
Opening: Rams -7.5 | Total around 48
Current: Rams -7 | Total 48.5
DK Split: Giants 82% bets, 79% money
New York's Week 1 performance generated immediate support, pushing Los Angeles onto the key number of seven.
Betting Takeaway: The Giants are attracting both tickets and money. Whether the Rams fall below seven is one of the most important Week 2 numbers to monitor.
Week 2 Market Takeaways
The most significant spread moves have come in Lions-Bills, Vikings-Bears, Raiders-Chargers, Dolphins-49ers and Seahawks-Cardinals. Quarterback injuries are contributing to some adjustments, while Week 1 performance has driven others.
The betting splits may be even more revealing. The Jets have 90 percent of spread money on 57 percent of tickets, Houston has 83 percent on 38 percent of tickets and New England has 76 percent despite receiving only 43 percent of wagers.
Meanwhile, Philadelphia, Tampa Bay, San Francisco and Buffalo are attracting heavy support from both tickets and money.
These are still early-week numbers. Betting splits will become more representative as volume increases, while Wednesday through Friday practice reports could produce another round of movement before kickoff.
INJURY REPORT
| Player | Team | Pos. | Injury / Issue | Week 2 Status | When Injured | Impact /10 | Primary Impact |
| Kyler Murray | MIN | QB | Concussion | Expected OUT | Week 1 | 10.0 | Carson Wentz expected to start; major spread/total impact |
| Sam Darnold | SEA | QB | Glute/soft tissue | OUT | Week 1 | 10.0 | Drew Lock expected to start; major offensive downgrade |
| Myles Garrett | LAR | EDGE | Knee | OUT / IR — surgery | Preseason/Week 1 | 9.5 | Major loss to pass rush and overall defense |
| Tua Tagovailoa | ATL | QB | Oblique | Questionable | Pre-Week 1 | 9.5 | Starting-QB uncertainty; major betting impact |
| A.J. Brown | NE | WR | Ankle | OUT / IR | Pre-Week 1 | 9.0 | Major target-share/offensive impact |
| Josh Jacobs | GB | RB | Commissioner's Exempt List | OUT | Pre-Week 1 | 9.0 | Major loss to running game; availability issue, not injury |
| Landon Dickerson | PHI | OG | Knee | OUT / IR | Pre-Week 1 | 9.0 | Significant offensive-line downgrade |
| Zay Flowers | BAL | WR | Hamstring | Questionable | Week 1 | 8.5 | Major target-share and explosive-play impact |
| Ladd McConkey | LAC | WR | Ribs | Day-to-day | Week 1 | 8.5 | Major receiving/fantasy impact |
| Michael Penix Jr. | ATL | QB | Knee | Monitor | Preseason | 8.0 | Important because of Atlanta QB situation |
| Alvin Kamara | NO | RB | Knee/MCL | Expected OUT | Preseason | 8.0 | Major backfield redistribution |
| James Conner | ARI | RB | Foot | OUT / IR | Preseason | 8.0 | Backfield and short-yardage downgrade |
| Brock Bowers | LV | TE | Injury/recovery | Monitor | Pre-Week 1 | 7.5 | Major piece of passing game |
| Dylan Sampson | CLE | RB | Knee | Questionable | Week 1 | 7.0 | Cleveland RB rotation |
| Henry To'oTo'o | HOU | LB | Shoulder | Expected OUT | Week 1 | 7.0 | Run-defense/linebacker downgrade |
| Malik Hooker | DAL | S | Forearm | Likely OUT | Week 1 | 7.0 | Dallas secondary downgrade |
| Brian Thomas Jr. | JAX | WR | Shoulder | Questionable / Monitor | Week 1 | 6.5 | Significant target-share impact |
| DeMarvion Overshown | DAL | LB | Hamstring | Questionable | Week 1 | 6.5 | Coverage/run-defense impact |
| Christian Mahogany | DET | OG | Hip | DNP Monday | Week 1 | 6.0 | Offensive-line concern for Thursday |
| Barryn Sorrell/Miller | DET | OT | Knee | DNP Monday | Week 1 | 6.0 | Additional offensive-line concern |
| Terrel Bernard | BUF | LB | Calf | Limited Monday | Existing | 6.0 | Important matchup impact vs. Detroit |
| Frankie Luvu | WAS | LB | Groin | Monitor | Week 1 | 6.0 | Washington defensive impact |
| Ja'Kobi Lane | BAL | WR | Wrist | Monitor | Week 1 | 6.0 | More important if Flowers unavailable |
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