This article is part of our Yahoo DFS Soccer series.
2:45 pm: Arsenal vs. AFC Bournemouth
2:45 pm: Southampton vs. Fulham
3:00 pm: Chelsea vs. Tottenham Hotspur
3:00 pm: Crystal Palace vs. Manchester United
3:00 pm: Liverpool vs. Watford
3:00 pm: Manchester City vs. West Ham United
Sergio Aguero, MCI v. WHU (£27): Aguero has the highest goal-scoring odds on the slate among expected starters, and Manchester City are the biggest favorites with the most implied goal scored. Wednesday's slate is a drastic change from Tuesday's due to the top six teams being included, giving us the likes of Aguero, Mohamed Salah (£26) and Eden Hazard (£27) all in the same price range. Aguero and Salah both have more favorable matchups than Hazard's home game against Tottenham, and Aguero has scored 16-plus points in four of his past five matches. If you like City's matchup and want to stack their attack, Raheem Sterling (£25) has scored at least 13 points in four of his past five starts, though the one outlier was a 0.65 dud against Newcastle. Leroy Sane (£24) is the cheapest of the three City forwards but doesn't offer enough savings to make much of a difference, especially with Aguero being a clear-cut choice. The Argentine will likely be one of the highest-owned players on the slate.
Harry Kane, TOT at CHE (£24): Wednesday's best matchup is Chelsea v. Tottenham, which also gives us a few different attacking options. Kane bounced back from a five-week absence to find the back of the net against Burnley and surprisingly play the full 90 last weekend. Prior to the injury, Kane had five straight performances of 10-plus points and wasted no time in extending that streak against the Clarets. His injury layoff makes him slightly cheaper than he would have been had he been consistently playing, making him worth targeting due to the savings. I mentioned Hazard earlier, but in my opinion, Willian (£21) might be a better pivot option due to his cheaper price. Son Heung-Min (£23) carried the scoring load while Kane was sidelined but produced a 1.65-point outing against Burnley.
Michy, CRY v. MUN (£14): Batshuayi is off and running, as he found the back of the net in his first start for Crystal Palace during Saturday's win over Leicester City. The sample size doesn't give a whole lot of confidence, but at the same point, we're going to need to find a cheap option on this slate due to all of the talent to pay up for. Manchester United's back line is intact for the most part, but that can't be said for the rest of their lineup, which could allow Palace to spring an upset when they host the Red Devils. Michy is averaging 6.53 shots and 2.90 shots on goal per 90 minutes, which is absurd and unsustainable, but even if he hits a fraction of that, he'll be worth rostering against United. Wilfried Zaha (£20) is a bit safer, though you'll lose out on the savings Michy brings. Two other cheap forwards to keep an eye on are Daniel Sturridge (£16) and Divock Origi (£10) due to Roberto Firmino (£21) questionable due to an ankle injury. Meanwhile, former Red Dominic Solanke (£10) is minimum priced and put up a solid 8.15 against Wolverhampton last time out.
Paul Pogba, MUN at CRY (£23): After looking at the injury report for Wednesday's match against Crystal Palace, United are lucky to still be able to count on an unscathed Pogba. He bounced back from his red card against Paris Saint-Germain to score 8.4 points in Sunday's draw with Liverpool, which isn't ideal at this price. We'll need more from him against Palace to justify the price, especially with Christian Eriksen (£23) and Kevin De Bruyne (£24) in a similar price range. Pogba has shown his fantasy floor to be around nine points, with his last Premier League outing below 8.4 points coming back in December. The pile of injuries United are facing will force Pogba to be the main man, which is no different than what he's been doing over the past two months.
Ryan Fraser, BOU at ARS (£18): Injuries to David Brooks, Callum Wilson and Junior Stanislas have given Fraser a majority of set pieces, which has given him a floor of around six points in his past three matches. A trip to Arsenal isn't the most ideal matchup, though he did manage 7.05 points in their previous meeting, which would be enough to justify his price. In that same matchup, Henrikh Mkhitaryan (£19) is coming off a goal and assist against Southampton and has more favorable odds, though another 18.85 points will be tough to replicate. Granit Xhaka (£17) is the main set-piece taker for Arsenal and has a relatively safe floor, but he is always susceptible going into the referee's book.
Nathan Redmond, SOU v. FUL (£15): Redmond has almost been operating as the lone striker for Southampton since Danny Ings went down with a hamstring injury on Feb. 2. The results have been mixed against Cardiff City and Arsenal, but Fulham offer another opportunity for Redmond to lead the line against a bad defense. It is worth noting that Fulham allow the most shots, shots on target and accurate crosses of any team on the slate, which provides a decent platform to roll the dice on Redmond, especially if you're trying to graduate up to the more expensive strikers on Liverpool or Manchester City. Jean Michael Seri (£15) will be on the other side of the pitch and has been able to produce at least five points in his past four starts.
Virgil van Dijk, LIV v. WAT (£16): Anfield has been a fortress for Liverpool this season, as they haven't lost in their past 34 matches across all competitions. A big reason for that is van Dijk's ability to organize the backline. Both Liverpool and Manchester City are heavy favorites at home and have the highest clean sheet odds, and van Dijk is the safest play of their defenders due to his high passing numbers, regularly surpassing 100 completed passes. Trent Alexander-Arnold (£16) was rested against Manchester United, while Andrew Robertson (£17) is one of the most expensive defenders despite registering over six fantasy points once in his past five matches. Joel Matip (£15) doesn't offer much savings but is the cheapest of Liverpool's probable starters.
Nicolas Otamendi, MCI v. WHU (£15):Aymeric Laporte and John Stones have been ruled out for the West Ham match, which leaves Otamendi and Vincent Kompany (£12) as the likely starting central defenders. Both players should see plenty of the ball in possession and are cheaper than the more attacking options on the slate, while being favorites for the clean sheet bonus.
Calum Chambers, FUL at SOU (£13): Chambers hasn't lined up as a defender since October but continues to be classified as a defender. He's connected on at least 50 passes in each of his past four matches, while adding tackles and interceptions. It's tough to depend on any Fulham defender for the clean sheet bonus, but Chambers' position as a central midfielder keeps him involved in the attack and his floor around five points. The savings he offers makes him hard to overlook, particularly in a matchup with the 18th-place team in the table as both sides look to make their way out of the relegation zone.
Angus Gunn, SOU v. FUL (£12): Yes, there are much safer options at goalkeeper, but none cheaper than Gunn, who replaced Alex McCarthy (£13) in the starting XI against Arsenal last weekend. Southampton have the fourth-best clean sheet odds and play in the match with the lowest implied goal total. Either Gunn or McCarthy offer plenty of savings and are worth a gamble in a stacked slate. Alisson (£17) and Ederson (£17) have the two highest clean sheet odds, and both are at home, while David de Gea (£17) is the same price but will travel to Crystal Palace. Ultimately, I think it's worth saving your money and opting for a Southampton goalkeeper or Sergio Rico (£13) in a match that could be devoid of scoring.