After finishing up a warm-weather training trip in Egypt, Wayne Rooney looks set to return to a Manchester United side that will also include newly-signed Juan Mata.
Aaron Ramsey looks set to return for Arsenal, after sitting out since Boxing Day with a thigh injury.
Yaya Toure suffered an ankle injury in Wednesday's FA Cup rout of West Ham, and he faces a late fitness test ahead of Sunday's match at Newcastle.
Robin van Persie was a surprise member of Manchester United's starting XI last week, but suffered an injury in the Champions League on Tuesday and will now be out a month.