Wayne Rooney is making a surprise return from a toe injury, but one of his striker teammates might provide the best value this gameweek.
Christian Benteke has been ruled out for the entire holiday period due to the knee injury he's been playing through over the past month.
Sergio Aguero is expected to miss at least a month due to the calf injury he suffered in last weekend's tilt with Arsenal.
Robin van Persie was a surprise member of Manchester United's starting XI last week, but suffered an injury in the Champions League on Tuesday and will now be out a month.
Robin van Persie has missed four games in a row and doesn't appear ready for this weekend's match against Newcastle.
Vincent Kompany has been deemed fit and is expected to start Wednesday against West Brom.
Vincent Kompany was held out of Manchester City's Champions League clash against Viktoria Plzen on Wednesday but looks set to return this weekend.
Theo Walcott looks set to return for Arsenal's important match against surprising Southampton on Saturday.
Vincent Kompany's thigh injury will keep him out again.
Theo Walcott is getting close to a return but an appearance this weekend is still unlikely.