Sebastian Giovinco was slated to play for Italy over the international break, which MLS plays through, but an adductor injury will keep him on the sidelines.
The Sounders could desperately use Clint Dempsey back in the lineup to pair with Obafemi Martins, but he remains questionable because of a hamstring injury.
Mauro Diaz is questionable for Saturday's match at Vancouver because of a quad injury that held him out last weekend. D.J. Trainor breaks down the other injury news heading into the weekend.
RotoWire's D.J. Trainor breaks down the latest injury news ahead of Major League Soccer's two-game Wednesday slate of games.
David Villa is high up on the goal expectancy projection for Week 22, though there are a few players with better chances.
Major League Soccer's leading goal scorer, Kei Kamara, has a great matchup this weekend against a Chicago side that he scored against just days ago.
New York City FC's David Villa leads the goal expectancy list this week, and he's one of only two players projected to take at least five shots, with two on goal.
The form table appears to be upside down, as Kei Kamara and the Columbus Crew find themselves with the fewest points in all of Major League Soccer in their last six games.
RotoWire's JD Bazzo thinks Juan Agudelo could be a good contrarian play, as most people will likely move toward teammate Charlie Davies, who has a goal in four straight games.
The reigning MLS Goalkeeper of the Year keeps the top spot in JD Bazzo's preseason rankings.
Coming off a 2014 MLS Cup win, Omar Gonzalez leads JD Bazzo's fantasy defender rankings.