With a number of key attackers missing, RotoWire's JD Bazzo is looking for Giovani dos Santos to step up Saturday against the Crew.
Orlando City continues to fight for a playoff spot, but they'll face off against New York City FC this weekend without Kaka, who is suspended for the match.
RotoWire's D.J. Trainor breaks down all the injury news ahead of this weekend's slate of MLS matches, including Javier Morales, who is questionable with a hip injury.
Columbus' Kei Kamara is atop the goal expectancy list for MLS' two-game slate on Wednesday.
David Villa has six goals in his last four games and will next face off against a Montreal side he's burned for three goals and one assist in two previous meetings.
Sebastian Giovinco was unable to play in the MLS All-Star Game because of a heel injury, but he has a shot at getting back on the pitch for Toronto FC on Saturday.
David Villa is high up on the goal expectancy projection for Week 22, though there are a few players with better chances.
Major League Soccer's leading goal scorer, Kei Kamara, has a great matchup this weekend against a Chicago side that he scored against just days ago.
New York City FC's David Villa leads the goal expectancy list this week, and he's one of only two players projected to take at least five shots, with two on goal.
Blas Perez has always been known as a streaky scorer, and with two goals in Week 2, it may be time for fantasy owners to pounce.