Paris Saint-Germain are heavy favorites away to St. Etienne on Friday, and with Neymar still sidelined due to injury, Edinson Cavani will continue to shoulder a bigger scoring load.
Arsenal picked up two important away goals in the first leg, and they'll look to finish off AC Milan at the Emirates on Thursday.
Atletico Madrid are the biggest favorites and have the highest implied goal total on Thursday's early Europa League slate, which means many eyes will be on Antoine Griezmann.
Inter Milan will be without Mauro Icardi and Ivan Perisic on Saturday, which could open up some value plays as they travel to take on Genoa.
Guingamp have four clean sheets in their last five Ligue 1 matches, and they'll look to do it again Friday against Strasbourg.
Despite possibly being without Philippe Coutinho, Liverpool are the biggest favorites on Wednesday's Champions League slate, and Mohamed Salah could have a major impact.
Some fantasy managers may stay away from Real Madrid because they're up against Tottenham, but RotoWire's Schuyler Redpath says not to shy away from Marcelo.
Monaco aren't the biggest favorites on Tuesday's eight-game Champions League slate, but bookmakers are still expecting Radamel Falcao to have a big impact.
Radamel Falcao has 11 goals in seven Ligue 1 matches this season, and he'll look to bag his first one in the Champions League Tuesday against Porto.
Cristiano Ronaldo hasn't been able to play during Real Madrid's La Liga matches due to suspension, and he'll look to take out his frustrations on Apoel Nicosia on Wednesday.
Bafetimbi Gomis has the best goal-scoring odds for Friday's three-game interleague slate, which includes matches from La Liga, Ligue 1 and the FA Cup.
While he doesn't have the goal upside of some of his teammates, Real Madrid's Toni Kroos still offers plenty for fantasy managers.
RotoWire's Andrew Laird breaks down the betting odds for Thursday's Europa League slate and focuses on some key players who could repeat their excellent first-leg performances.