Napoli are heavily favored at home against FC Zurich on Thursday, as they enter the second leg of their round of 32 tie up 3-1 on aggregate.
Chelsea are heavily favored away to Malmo on Thursday, but will fantasy players be able to rely on Eden Hazard?
Atletico Madrid are one of three big favorites on Thursday's early eight-game slate, which means plenty of fantasy players could be eying Antoine Griezmann.
Atletico Madrid travel to Copenhagen for Thursday's Europa League match, but even being away from home doesn't stop them from being the biggest favorites.
Roma will book their place in the knockout rounds with a win against Qarabag on Tuesday, and they'll rely on Edin Dzeko to put them ahead.
No one has scored more Champions League goals this season than Paris Saint-Germain, and they'll look to add to their total against Celtic, who have allowed more goals than all but three teams.
Fantasy players are likely to flock to Neymar for Tuesday's eight-game Champions League slate, with PSG heavily favored against Anderlecht.
The heavy hitters are out for Wednesday's seven-game Champions League slate, with Paulo Dybala looking to break a three-match goalless drought.
Slovakia are the biggest favorites on Sunday's early six-game slate, but Poland, England and Denmark are also expected to dominate their matches.
England are heavy favorites as they host Slovenia on Thursday, and bookmakers are expecting Harry Kane to make an impact.
Paulo Dybala has 10 goals in six Serie A matches this season, and his share of set pieces makes him one of the best fantasy options available on Wednesday's seven-game slate.
Miralem Pjanic's role for Juventus allows him to pick up fantasy points all over the pitch, giving him a solid floor Wednesday against Olympiacos.
Juventus are strong favorites at home against Olympiacos on Wednesday, which means plenty of fantasy managers could be turning to Gonzalo Higuain.
Manchester United are heavily favored over FC Basel on Tuesday, and fantasy owners could get plenty of points out of midfielder Henrik Mkhitaryan.