This article is part of our Exploiting the Matchups series.
In previous years, I leveraged the intro of this column to highlight some running back handcuff stashes that could pay huge dividends if an injury-heavy season continued to claim victims. Since we're seeing a similar trend this year at RB, it's worth repeating that exercise.
Many teams won't be able to take advantage because of roster limits, but especially for the owners of the starters in front of these guys, do what you can to squeeze these handcuffs onto your bench. After all, if these guys took over for an injured star, they could be league-winners.
1. C.J. Anderson, CAR: Christian McCaffrey has dominated this backfield with 158 touches to Anderson's 23, and if that extra workload ends up breaking the 205-pound tailback, his veteran backup could go off down the stretch. After all, Anderson is just one year removed from a 1,000-yard rushing season, and the Panthers draw the Buccaneers, Browns, Saints and Falcons in Weeks 13-16.
2. Spencer Ware, KC: Elite offense plus good talent equals huge production. That's the formula via which Ware could become a league winner should any serious ailment take down Kareem Hunt's tree trunk legs. Five of Ware's 33 touches have gone for more than 20 yards, and he's tallied over 80 scrimmage yards in a complementary role twice in the last three games. Before Hunt's arrival and his injury last season, Ware looked like a true three-down workhorse after posting 1,368 scrimmage yards during 14 games in 2016.