1.  
Rush Att
252
Rush Yds
1126
Rush TD
10
Rush Avg
4.5
Rec
88
Rec Yds
767
Rec TD
4
Rec Avg
8.7
After not missing a game through his first three NFL seasons and seeing heavy workloads in the last two, McCaffrey signed a big contract extension over the summer and promptly broke down. Ankle, shoulder and thigh injuries limited him to only three weeks of action in 2020, and while he scored six touchdowns in those three contests and was still his usual electric self when he was on the field, it was not what Carolina was expecting when they made him the highest-paid running back in the league. When he's in top form, McCaffrey is an elite pass-catching option out of the backfield who is tough for defenders to get their hands on in the open field, and new head coach Matt Rhule showed no hesitation in using his superstar at the goal line, as all six of McCaffrey's TDs came from inside the 10-yard line. His per-game workload was essentially the same as his usage under the previous regime, and none of last year's injuries appear to be long-term concerns. The Panthers also did little prior to the draft to add depth to their backfield, a strong indication McCaffrey will once again handle the type of role that could lead to 400-plus touches if he plays 15 or 16 games.
2.  
RB  MIN
Rush Att
290
Rush Yds
1366
Rush TD
12
Rush Avg
4.7
Rec
56
Rec Yds
477
Rec TD
2
Rec Avg
8.5
Cook once again wasn't able to suit up for a full schedule, missing Week 6 with a minor groin strain before leaving the team in Week 17 after the tragic death of his father, but his production when he was on the field was phenomenal. He finished second in the league in rushing yards and rushing TDs, behind only Derrick Henry, and no back saw more carries inside the 5-yard line or broke more tackles than Cook. His combination of strength, elusiveness and breakaway speed makes him perhaps the most dangerous pure runner in the NFL, and while Cook doesn't have the route-running ability of some other three-down backs, he's recorded at least 40 catches in three straight seasons and has proven himself capable as a receiver. The circumstances around him remain extremely favorable as well. The offensive line figures to get better with Ezra Cleveland and Garrett Bradbury solidifying the middle, while head coach Mike Zimmer is still predisposed to a ground-and-pound gameplan. New OC Klint Kubiak did come up through the ranks focused on the passing game, but his father Gary was no stranger to dominant rushing attacks during his coaching career. One of these years Cook is going to play 16 games, and 2,000-plus scrimmage yards will likely follow.
3.  
RB  NYG
Rush Att
283
Rush Yds
1328
Rush TD
11
Rush Avg
4.7
Rec
58
Rec Yds
522
Rec TD
2
Rec Avg
9.0
For the second straight season Barkley dealt with a lower-body injury but this time it was far more devastating, as he blew out his right knee in Week 2 and missed the rest of the campaign after ACL surgery. The promise he showed in his dazzling rookie campaign is beginning to fade in the rearview mirror, but when he's healthy, Barkley should still be a dynamic three-down back who can break off a long gain with any given touch. Assuming he's 100 percent for the start of the season, he should slot back in as the only game in town in the Giants backfield, but that role may not come with the same volume he saw in 2018. The team expended significant resources in the offseason to bolster its passing game by signing Kenny Golladay, which suggests more responsibility will be put on Daniel Jones' arm to move the chains. On the other hand, Jason Garrett is still offensive coordinator, and his track record suggests he's quite content to ride his bell-cow back as much as he can. Getting Nate Solder back at left tackle after he opted out of 2020 will also help bolster the team's offensive line, a unit which has been a weak spot on the roster throughout Barkley's career. There's no denying his upside, but the 24-year-old carries a lot of question marks heading into Week 1.
4.  
RB  TEN
Rush Att
330
Rush Yds
1523
Rush TD
15
Rush Avg
4.6
Rec
17
Rec Yds
118
Rec TD
1
Rec Avg
6.9
It's still mind-boggling that as recently as 2018, the Titans thought Henry needed to split touches with Dion Lewis. Since then, he's proven to be the most physically dominant back in the league, winning consecutive rushing crowns and posting the eighth 2000-yard campaign in NFL history in 2020. Henry hasn't wilted as his carries have increased either, keeping his yards per carry above 5.0 for the second straight season and finishing second to Dalvin Cook in broken tackles. In fact, Henry seems to thrive on being able to dish out punishment to opposition defenders, and if you only counted his yards after contact in 2020, he still would have finished fourth in the league in rushing. There's just nothing subtle about his running style, as he uses his 6-3, 247-pound frame to bludgeon his way through holes and over would-be tacklers, but his nimble feet and surprising speed in the open field are what set him apart from other large backs who get stuck in short-yardage roles. The Titans will be looking for 2020 third-round pick Darrynton Evans to take a step forward in his development become a reliable passing-down option, but there's little else on the depth chart behind the duo as the team has clearly learned its lesson. Henry should once again see a big workload, pound out yards and wear down defenses, and open things up for Ryan Tannehill to do damage in play-action.
5.  
RB  IND
Rush Att
290
Rush Yds
1411
Rush TD
13
Rush Avg
4.9
Rec
47
Rec Yds
336
Rec TD
1
Rec Avg
7.1
When Marlon Mack ruptured his Achilles in Week 1 it was assumed Taylor would immediately erupt, and the rookie did post his first 100-yard rushing game in Week 2, but it took him a while to get going after that. Between Weeks 3 and 10, he failed to top 68 yards as he adjusted to the NFL, but down the stretch Taylor broke through and became the player Indianapolis thought it was drafting in the second round. Over his final six regular-season contests, Taylor amassed 741 rushing yards and seven TDs, including a mammoth 253 yards and two scores in Week 17 to help the Colts lock up a playoff spot. The 22-year-old has an enviable blend of power, speed and agility, and he showed good patience in waiting for Indy's elite offensive line to open holes that would allow him to explode into the second level. Taylor isn't a natural pass-catcher, but he's adequate in that area and with Nyheim Hines on the roster he won't have to handle the bulk of those duties. Mack also signed a one-year deal to return and provide some insurance, but after the way Taylor closed 2020, it's hard to see him working in any kind of committee. He hasn't yet reached his ceiling, and more work at the goal line (he barely saw half of the Colts' red-zone carries, a rate well behind the likes of Josh Jacobs or Ezekiel Elliott) could push his production into the stratosphere.
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