Injuries: Isaac Seumalo (foot), Brett Toth (knee), Lane Johnson (questionable), Jack Driscoll (ankle)
Backups: (T): Andre Dillard (G): Jack Anderson (C): Cam Jurgens
Fantasy Impact: The retirement of Pro Bowl RG Brandon Brooks, even after numerous injury-plagued years, is a notable blow. There's still cause for optimism surrounding this unit, though. While Jalen Hurts still has a ways to go in his efforts to prove himself as a franchise QB, his athleticism should be valuable in covering up deficiencies along the O-line. Rookie second-round pick Cam Jurgens will get a chance to develop behind Jason Kelce (on a one-year deal) before taking over.
Injuries: Jack Conklin (kneecap), Chris Hubbard (triceps)
Backups: (T): Chris Hubbard (G): Michael Dunn (C): Ethan Pocic
Fantasy Impact: Losing J.C. Tretter isn't an ideal development, but the Browns still boast one of the top O-lines in the league. LG Joel Bitonio, RG Wyatt Teller, RT Jack Conklin and LT Jedrick Willis are all among the league's best options at their positions, and if a replacement for Tretter can be found, this unit could legitimately be without any real weakness among its starters. That is, of course, dependent on health, and injuries weren't kind to the Browns in 2021. Conklin ultimately being forced to undergo season-ending surgery was a huge blow for Cleveland's offense, but he should be healthy to start the 2022 campaign.
Injuries: Josh Ball (ankle)
Backups: (T): Josh Ball (G): Conner McGovern (C): Braylon Jones
Fantasy Impact: The Cowboys' O-line is undergoing a seachange, having lost La'el Collins to the Bengals and Connor Williams to Miami. Standouts LT Tyron Smith and RG Zack Martin remain, but this is a unit now boasting multiple weak points. Top-five upside may no longer be in view for Dallas' protection, a development which would bode poorly for Dak Prescott. The addition of rookie first-round pick Tyler Smith should do a fair amount to keep things steady.
Injuries: Lucas Niang (kneecap)
Backups: (T): Geron Christian (G): Nick Allegritti (C): Darryl Williams
Fantasy Impact: The memory of Kansas City's loss to the Buccaneers in Super Bowl LV, in which the O-line was unable to give Patrick Mahomes any sort of consistent protection, led to a full overhaul of the unit. Gone are longtime tackles Eric Fisher and Mitchell Schwartz. Trading for Orlando Brown from Baltimore certainly solidified the LT spot, and his receiving the franchise tag is no surprise. The Chiefs could potentially have a top-five unit if things mesh right, but the starting RG spot remains a question.