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San Francisco 49ers vs Carolina Panthers in week.

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Sportsbook
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ESPN Bet ESPN Bet
Hard Rock Hard Rock
Panthers
19.8 Pts
49ers
26.8 Pts
Monday November 24, 2025 at 8:15 PM ET
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Moneyline
ESPN Bet ESPN Bet
-280
PROBABILITY with vig removed
CAR Panthers Win (+230)
29.1%
SF 49ers Win (-280)
70.9%
LINE MOVEMENT
No changes have been recorded yet.
No changes have been recorded yet.
Spread
ESPN Bet ESPN Bet
-7.0
PROBABILITY with vig removed
CAR Win or Lose By < 7 Pts(-110)
50.0%
SF Win By 7+ Pts(-110)
50.0%
LINE MOVEMENT
No changes have been recorded yet.
No changes have been recorded yet.
No changes have been recorded yet.
Over Under
ESPN Bet ESPN Bet
46.5
Points
PROBABILITY with vig removed
Over 47 Total Points(-110)
50.0%
Under 47 Total Points(-110)
50.0%
LINE MOVEMENT
No changes have been recorded yet.
No changes have been recorded yet.
No changes have been recorded yet.
Player Props
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CAR
Panthers Injury Report
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SF
49ers Injury Report
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CAR
Panthers Lineup
Inactives
    None reported yet.
SF
49ers Lineup
Inactives
    None reported yet.
CAR
Panthers News
#3 LDE
Popo Aumavae: Reverts to IR
May 9th
Aumavae (Achilles) cleared waivers and reverted to injured reserve Friday, Aaron Wilson of KPRC 2 Houston reports.
#7 RB
Jonathon Brooks: Won't play in 2025 after PUP move
May 8th
The Panthers are placing Brooks on the physically unable to perform list, ruling him out for the entire 2025 season.
SF
49ers News
#2 K
Greg Joseph: Headed to 49ers
May 16th
The 49ers are slated to sign Joseph, Matt Barrows of The Athletic reports.
#1 QB
Brock Purdy: Gets massive five-year extension
May 16th
Purdy and the 49ers agreed to terms Friday on a five-year, $265 million contract extension, Tom Pelissero of NFL Network reports.
#5 LCB
Tre Tomlinson: Reverts to IR
May 13th
Tomlinson (undisclosed) reverted to the 49ers' injured reserve Tuesday, per the NFL's transaction log.
#2 LT
Andre Dillard: Links up with 49ers
May 9th
The 49ers signed Dillard (concussion) on Friday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#3 QB
Kurtis Rourke: Won't play in rookie camp
May 9th
Rourke (knee) won't participate in the 49ers' rookie camp, Matt Maiocco of NBC Sports Bay Area reports.