Juan Cuadrado could be in a more attacking role Tuesday and already on set pieces, RotoWire's Ryan Belongia thinks he's the top defender to target for the two-game slate.
Tottenham and Liverpool are big favorites against Southampton and Burnley, respectively, so fantasy players could tinker with the possibility of pairing Harry Kane and Mohamed Salah.
Potential rotation in the Liverpool attack could alter some fantasy lineups, but Mohamed Salah will be a popular option if he starts at home to Stoke City.
Liverpool look set to rest regular starters like Mohamed Salah and Roberto Firmino, which should open up a few key value plays when they host Stoke City at Anfield.
Desperate in his quest to win another Golden Boot, Harry Kane is likely to be taking as many shots as possible in Tottenham's match against Watford on Monday.
Harry Kane's recent injury has helped push his price down, and RotoWire's Schuyler Redpath is happy to take advantage, even in a tough matchup against Man City.