A two-game slate during an FIFA international break reduces the player pool a bit, but there's still some firepower available Wednesday.
An away match at Yankee Stadium to face New York City FC has Golden Boot front-runner Kei Kamara high up the rankings this weekend.
David Villa has six goals in his last four games and will next face off against a Montreal side he's burned for three goals and one assist in two previous meetings.
David Villa is high up on the goal expectancy projection for Week 22, though there are a few players with better chances.
Jozy Altidore has returned to Toronto FC after being dropped from the USMNT Gold Cup roster, but a number of key MLS players won't play this weekend.
New York City FC's David Villa leads the goal expectancy list this week, and he's one of only two players projected to take at least five shots, with two on goal.