49ers vs Titans Odds, Lines, Spreads & Totals 2025
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ESPN Bet 
Hard Rock 
Titans
19.0 Pts
49ers
26.5 Pts
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Moneyline
DraftKings
PROBABILITY with vig removed
Titans Win (+270)
25.9%
49ers Win (-340)
74.1%
LINE MOVEMENT
Spread
DraftKings
PROBABILITY with vig removed
Win or Lose By < 8 Pts(-110)
50.0%
Win By 8+ Pts(-110)
50.0%
LINE MOVEMENT
No changes have been recorded yet.
No changes have been recorded yet.
No changes have been recorded yet.
Over Under
DraftKings Points
PROBABILITY with vig removed
Over 46 Total Points(-110)
50.0%
Under 46 Total Points(-110)
50.0%
LINE MOVEMENT
No changes have been recorded yet.
No changes have been recorded yet.
No changes have been recorded yet.
Player Props
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Titans Injury Report
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49ers Injury Report
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Titans Lineup
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QB
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RB
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WR
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WR
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WR
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TE
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K
Inactives
None reported yet.
49ers Lineup
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QB
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RB
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WR
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WR
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WR
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TE
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K
Inactives
None reported yet.
Titans News
#6 TE
Drake Dabney: Signs with Tennessee
May 12th
Dabney signed with the Titans on Monday, Jim Wyatt of the team's official site reports.
#13 WR
TJ Sheffield: Joins Tennessee
May 12th
Sheffield signed with the Titans on Monday, Jim Wyatt of the team's official site reports.
#4 RB
Kalel Mullings: Limited at rookie minicamp
May 10th
Titans head coach Brian Callahan said Saturday that Mullings (abdomen) is recovering from core muscle surgery and will be limited at rookie minicamp, John Glennon of NashvillePost.com reports.
#2 SS
Kevin Winston Jr.: Not participating yet
May 10th
Titans head coach Brian Callahan said Saturday that Winston (knee) isn't ready to practice in full at rookie minicamp but will be on the practice field, John Glennon of NashvillePost.com reports.
#5 RB
Micah Bernard: Finds work with Tennessee
May 8th
The Titans signed Bernard as an undrafted free agent Thursday.
49ers News
#2 K
Greg Joseph: Headed to 49ers
May 16th
The 49ers are slated to sign Joseph, Matt Barrows of The Athletic reports.
#1 QB
Brock Purdy: Gets massive five-year extension
May 16th
Purdy and the 49ers agreed to terms Friday on a five-year, $265 million contract extension, Tom Pelissero of NFL Network reports.
#5 LCB
Tre Tomlinson: Reverts to IR
May 13th
Tomlinson (undisclosed) reverted to the 49ers' injured reserve Tuesday, per the NFL's transaction log.
#2 LT
Andre Dillard: Links up with 49ers
May 9th
The 49ers signed Dillard (concussion) on Friday, Jennifer Lee Chan of NBC Sports Bay Area reports.
#3 QB
Kurtis Rourke: Won't play in rookie camp
May 9th
Rourke (knee) won't participate in the 49ers' rookie camp, Matt Maiocco of NBC Sports Bay Area reports.