Sebastian Giovinco was slated to play for Italy over the international break, which MLS plays through, but an adductor injury will keep him on the sidelines.
The Sounders could desperately use Clint Dempsey back in the lineup to pair with Obafemi Martins, but he remains questionable because of a hamstring injury.
Mauro Diaz is questionable for Saturday's match at Vancouver because of a quad injury that held him out last weekend. D.J. Trainor breaks down the other injury news heading into the weekend.
Obafemi Martins looks set to return for the Sounders this weekend, but he could be without strike partner Clint Dempsey.
Kaka was a surprise absence Wednesday against Toronto, but he has stated that he will play Saturday against Philadelphia.
Michael Bradley was expected to miss multiple games with a calf injury, but he has a shot to play Wednesday against Orlando City.
Sebastian Giovinco was unable to play in the MLS All-Star Game because of a heel injury, but he has a shot at getting back on the pitch for Toronto FC on Saturday.
The Sounders could be getting a number of players back from the Gold Cup this weekend, but Obafemi Martins remains sidelined with a groin injury.
Jozy Altidore has returned to Toronto FC after being dropped from the USMNT Gold Cup roster, but a number of key MLS players won't play this weekend.
A few big name players are out with injuries, while the Gold Cup has taken a few more top stars like Toronto's Jozy Altidore.
A number of star players have already met up with their international teams for the Gold Cup, while a few others are sidelined with injuries.
RotoWire's D.J. Trainor runs through the MLS injury list heading into Wednesday's slate of games.