Injury news in soccer is notoriously sketchy, so while the below information should be used as a guide, always check the confirmed lineups before every match.
Note: this column is updated throughout the week as injury news is released.
v. 
PPL Park
Wednesday, June 24 at 7:00 p.m. EDT
Philadelphia Union
Out:Fernando Aristeguieta (ankle), Andre Blake (knee), Conor Casey (quadriceps), Michael Lahoud (quadriceps), Sebastian Le Toux (knee), Steven Vitoria (hamstring)
Probable:Eric Ayuk (ankle)
Seattle Sounders
Suspended:Clint Dempsey
Out:Chad Barrett (hamstring), Obafemi Martins (groin)
Questionable:Osvaldo Alonso (hamstring), Andres Correa (hip), Brad Evans (groin), Gonzalo Pineda (knee)
v. 
Mapfre Stadium
Wednesday, June 24 at 7:30 p.m. EDT
Columbus Crew
Questionable:Cedric Mabwati (international duty), Wil Trapp (concussion)
New England Revolution
Out:Darrius Barnes (knee), Jermaine Jones (groin)
v. 
ESPN Wide World of Sports Complex
Wednesday, June 24 at 7:30 p.m. EDT
Orlando City SC
Out:Kevin Molino (knee)
Questionable:Tony Cascio (back), Aurelien Collin (hamstring), Estrela (international duty), Martin Paterson (knee), Bryan Rochez (international duty)
Colorado Rapids
Out:Axel Sjoberg (knee)
Questionable:Juan Ramirez (hamstring)
v. 
Red Bull Arena
Wednesday, June 24 at 7:30 p.m. EDT
New York Red Bulls
Suspended:Sacha Kljestan
Out:Lloyd Sam (groin)
Questionable:Kemar Lawrence (international duty)
Real Salt Lake
Suspended:Kyle Beckerman
Out:Alvaro Saborio (personal), Chris Schuler (knee)
Questionable:Abdoulie Mansally (international duty), Jamison Olave (quadriceps), Elias Vasquez (international duty)
v. 
BMO Field
Wednesday, June 24 at 8:00 p.m. EDT
Toronto FC
Doubtful:Mark Bloom (quadriceps)
Questionable:Steven Caldwell (Achilles), Daniel Lovitz (knee), Clement Simonin (knee)
Montreal Impact
Out:Kenny Cooper (knee), Justin Mapp (elbow), Cameron Porter (knee)
Doubtful:Adrian Lopez (knee)
Questionable:Hassoun Camara (knee), Eric Miller (hamstring)
v. 
Toyota Park
Wednesday, June 24 at 8:30 p.m. EDT
Chicago Fire
Suspension:Matt Polster
Out:Shaun Maloney (back)
Doubtful:David Accam (hamstring), Patrick Nyarko (knee)
Questionable:Joevin Jones (international duty)
Probable:Harry Shipp (general soreness)
D.C. United
Suspended:Davy Arnaud
Questionable:Michael Farfan (hamstring), Sean Franklin (ankle), Collin Martin (groin), Chris Pontius (hip)
v. 
StubHub Center
Wednesday, June 24 at 11:00 p.m. EDT
Los Angeles Galaxy
Out:Brian Perk (ankle), Steven Gerrard (not with team)
Doubtful:Bradford Jamieson IV (concussion)
Questionable:Edson Buddle (groin), Todd Dunivant (calf)
Portland Timbers
Out:Ben Zemanski (knee)
Doubtful:Dairon Asprilla (ankle)
Probable:Alvas Powell (hamstring)
