Bryant appeared in 38 games for the Wizards during the 2019-20 season. He set new per-game career highs in points (12.1), rebounds (6.8), assists (1.9), threes (0.6) and steals (0.4). Bryant shot 59.9 percent from the field, a career-high 40.7 percent from three and 73.7 percent from the free-throw line. He set new single-game career highs of six assists and four blocks. His other single-game season highs were 23 points, 12 rebounds, three triples and two steals. Bryant's 23-point game was also arguably his best all-around performance of the season, and it occurred Nov. 27 against the Suns. He shot 9-of-11 from the field, 2-of-2 from three and 3-of-3 from the free-throw line while also providing nine rebounds and five assists. Bryant had six performances with at least 20 points, nine performances with at least 10 rebounds (eight were double-doubles) and four efforts with five-plus assists. He also had 11 games with at least one steal and 20 performances with at least one block. In the 10 games that Bryant saw at least 30 minutes, he averaged 17.2 points on 11.7 shots, 9.8 rebounds, 3.1 assists and 1.2 blocks.

Bryant played in 72 games and made 53 starts during his first season with the Washington Wizards. He finished the season by starting the final 10 games. Bryant averaged 10.5 points and 6.3 rebounds per game. On Dec. 22 he scored a career-high 31 points in a triple-overtime victory over the Phoenix Suns. In the game Bryant went a perfect 14-for-14 from the floor. That performance is tied for the fourth-most field goals made without a miss in a game in NBA history. Only Wilt Chamberlain has converted more field goals without a miss in an NBA game. On March 27 Bryant collected a career-high 19 rebounds, again against the Suns, as part of a 124-121 win. Over the course of the season, he led the Wizards in total rebounds (454) and blocks (67). Bryant finished the year with the fourth-highest field-goal percentage in the league (.616) and the highest two-point field-goal percentage (.685).

After two seasons at the University of Indiana, Bryant declared himself eligible for the 2017 NBA Draft. He was selected in the second round (42nd overall) by the Utah Jazz. He was then subsequently traded to the Los Angeles Lakers along with Josh Hart (pick No. 30) in exchange for Tony Bradley (pick No. 27). The rookie appeared in 15 games for Los Angeles and 27 contests for the G League South Bay Lakers. With L.A., Bryant averaged 1.5 points and 1.1 rebounds over 4.8 minutes per game. Bryant made his NBA debut on Dec. 23 during a four minute appearance in a home loss to the Trail Blazers. With South Bay, Bryant posted 19.7 points, 7.4 rebounds, 2.1 assists and 1.5 blocks per G League contest. On Dec. 15, the 6-foot-10 big man tallied 32 points, 10 rebounds and five assists for South Bay in a loss to Westchester. Bryant's best NBA game came on Apr. 11. He delivered six points, six rebounds, two blocks and one assist in a 115-100 win over the Clippers. The Los Angeles Lakers finished 35-47 and did not qualify for the playoffs.