Bryant appeared in 46 out of 72 games for the Wizards during the pandemic-shortened 2019-20 season and had 36 starts. The 22-year-old set new per-game career highs in points (13.2), rebounds (7.2), assists (1.8), threes (0.8) and steals (0.5). Bryant shot 58.1 percent from the field, a career-high 40.7 percent from three and 74.1 percent from the free-throw line. He set new single-game career highs of six assists, four steals and four blocks. On Nov. 27, Bryant delivered 23 points (9-11 FG), nine rebounds and five assists in a win at Phoenix. Bryant played particularly well during the Orlando seeding games. He started all eight games for the Wizards and averaged 18.6 points, 8.9 rebounds, 2.0 blocks, 1.9 made three-pointers and 1.4 steals per bubble contest. On Aug. 2, he had arguably his best game of the season with 30 points, 13 boards, three dimes and two blocks in a loss to the Nets. He finished the season on Aug. 13 leading the Wizards to victory over the Celtics with 26 points (10-15 FG), nine rebounds, four steals and two blocks. Bryant missed all of December and six games in January due to a foot injury.

Bryant played in 72 games and made 53 starts during his first season with the Washington Wizards. He finished the season by starting the final 10 games. Bryant averaged 10.5 points and 6.3 rebounds per game. On Dec. 22 he scored a career-high 31 points in a triple-overtime victory over the Phoenix Suns. In the game Bryant went a perfect 14-for-14 from the floor. That performance is tied for the fourth-most field goals made without a miss in a game in NBA history. Only Wilt Chamberlain has converted more field goals without a miss in an NBA game. On March 27 Bryant collected a career-high 19 rebounds, again against the Suns, as part of a 124-121 win. Over the course of the season, he led the Wizards in total rebounds (454) and blocks (67). Bryant finished the year with the fourth-highest field-goal percentage in the league (.616) and the highest two-point field-goal percentage (.685).

After two seasons at the University of Indiana, Bryant declared himself eligible for the 2017 NBA Draft. He was selected in the second round (42nd overall) by the Utah Jazz. He was then subsequently traded to the Los Angeles Lakers along with Josh Hart (pick No. 30) in exchange for Tony Bradley (pick No. 27). The rookie appeared in 15 games for Los Angeles and 27 contests for the G League South Bay Lakers. With L.A., Bryant averaged 1.5 points and 1.1 rebounds over 4.8 minutes per game. Bryant made his NBA debut on Dec. 23 during a four minute appearance in a home loss to the Trail Blazers. With South Bay, Bryant posted 19.7 points, 7.4 rebounds, 2.1 assists and 1.5 blocks per G League contest. On Dec. 15, the 6-foot-10 big man tallied 32 points, 10 rebounds and five assists for South Bay in a loss to Westchester. Bryant's best NBA game came on Apr. 11. He delivered six points, six rebounds, two blocks and one assist in a 115-100 win over the Clippers. The Los Angeles Lakers finished 35-47 and did not qualify for the playoffs.