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Virginia vs Louisville Odds

Virginia
27.5 Pts
Louisville
34.0 Pts
Saturday October 4, 2025 at 3:30 PM ET
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Moneyline
DraftKings DraftKings
-238
PROBABILITY with vig removed
UVa Cavaliers Win (+195)
32.5%
Lou Cardinals Win (-238)
67.5%
LINE MOVEMENT
Spread
DraftKings DraftKings
-6.5
PROBABILITY with vig removed
UVa Win or Lose By < 7 Pts(-108)
49.6%
Lou Win By 7+ Pts(-112)
50.4%
LINE MOVEMENT
Over Under
DraftKings DraftKings
61.5
Points
PROBABILITY with vig removed
Over 62 Total Points(-108)
49.6%
Under 62 Total Points(-112)
50.4%
LINE MOVEMENT
UVa
Cavaliers Injury Report
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Lou
Cardinals Injury Report
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UVa
Cavaliers News
#12 WR
Andre Greene: Out Saturday
Oct 2nd
Greene (undisclosed) has been ruled out for Saturday's game at Louisville, per the ACC availability report.
#3 RB
Noah Vaughn: Ruled out Saturday
Oct 2nd
Vaughn (ankle) has been ruled out for Saturday's game at Louisville, per the ACC availability report.
#5 RB
Davis Lane: Ruled out again
Oct 2nd
Lane (undisclosed) is out for Saturday's game at Louisville, per the ACC availability report.
#5 WR
Eli Wood: Questionable for Saturday
Oct 2nd
Wood (undisclosed) is questionable for Saturday's game at Louisville, per the ACC availability report.
#2 RB
Xavier Brown: 10 touches in win
Sep 30th
Brown totaled nine rushes for 60 yards and reeled in 1 of 2 targets for 15 yards and one touchdown during Friday's 46-38 overtime victory over Florida State.
#1 WR
Trell Harris: Slows up after big game
Sep 29th
Harris hauled in 3 of 5 targets for 45 yards during Friday's 46-38 overtime victory versus Florida State.
#2 WR
Cameron Ross: Efficient on five targets
Sep 29th
Ross reeled in all five targets for 34 yards during Friday's 46-38 overtime victory over Florida State.
#1 RB
J'Mari Taylor: Massive workload in win
Sep 29th
Taylor totaled 27 carries for 99 yards and one touchdown and hauled in all three targets for 16 yards during Friday's 46-38 overtime win over Florida State.
#4 RB
Harrison Waylee: Returns to minimal role
Sep 29th
Waylee totaled four carries for 15 yards during Friday's 46-38 overtime win versus Florida State.
#1 QB
Chandler Morris: Scores five times in upset
Sep 29th
Morris was 26-for-35 passing for 229 yards, two touchdowns and three interceptions during Friday's 46-38 overtime win over Florida State. He also had eight rushes for 37 yards with three touchdowns.
#4 QB
Grady Brosterhous: Not listed on injury report
Sep 24th
Brosterhous (undisclosed) is not listed on the injury report for the Week 5 game against Florida State on Friday.
Lou
Cardinals News
#4 RB
Jamarice Wilder: Ruled out again
Oct 2nd
Wilder (undisclosed) is out for Saturday's game versus Virginia, per the ACC availability report.
#3 RB
Keyjuan Brown: Questionable for Saturday
Oct 2nd
Brown (undisclosed) is questionable for Saturday's game versus Virginia, per the ACC availability report.
#2 RB
Duke Watson: Probable or better ahead of UVA
Oct 2nd
Watson (lower leg) is probable or better heading into Louisville's game against Virginia in Week 6, Pete Nakos of On3.com reports.
#1 RB
Isaac Brown: Considered probable vs. UVA
Oct 2nd
Brown (lower leg) is reportedly probable if not better for Louisville's clash with Virginia on Saturday, per Pete Nakos of On3.com.
#2 TE
Jaleel Skinner: Scores vs. Panthers
Sep 29th
Skinner caught all three targets for 25 yards and one touchdown during Saturday's 34-27 victory versus Pittsburgh.
#2 WR
Caullin Lacy: Another eight-catch, 90-yard day
Sep 29th
Lacy logged eight receptions (on 12 targets) for 95 yards during Saturday's 34-27 win versus Pittsburgh.
#1 WR
Chris Bell: Huge day in Week 5 win
Sep 29th
Bell caught 10 of 16 targets for 135 yards and one touchdown during Saturday's 34-27 win over Pittsburgh.
#1 QB
Miller Moss: Best day yet as a Cardinal
Sep 29th
Moss completed 33 of 51 passes for 339 yards, three touchdowns and one interception during Saturday's 34-27 win against Pittsburgh. He also had four rushes for -15 yards with one touchdown.
#6 RB
Shammai Gates: Out Saturday
Sep 25th
Gates (undisclosed) is out Saturday at Pittsburgh, Abby Schnable of the Pittsburgh Post-Gazette reports.
#4 QB
Travis Egan: Out Saturday
Sep 25th
Egan (undisclosed) is out for Saturday's game at Pittsburgh, Abby Schnable of the Pittsburgh Post-Gazette reports.
#3 WR
Dacari Collins: Solid outing vs. BGSU
Sep 22nd
Collins gathered in all four targets for 84 yards during Saturday's 40-17 victory against Bowling Green.
#1 TE
Nate Kurisky: Suits up but minimally invovled
Sep 21st
Kurisky (hand) caught their only target for negative three yards during Saturday's 40-17 victory over Bowling Green.