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Pittsburgh vs Syracuse Odds

Pittsburgh
32.5 Pts
Syracuse
22.0 Pts
Saturday October 18, 2025 at 7:30 PM ET
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Moneyline
DraftKings DraftKings
-410
PROBABILITY with vig removed
Pitt Panthers Win (-410)
77.2%
Syr Orange Win (+320)
22.8%
LINE MOVEMENT
Spread
DraftKings DraftKings
-10.5
PROBABILITY with vig removed
Pitt Win By 11+ Pts(-110)
50.0%
Syr Win or Lose By < 11 Pts(-110)
50.0%
LINE MOVEMENT
Over Under
DraftKings DraftKings
54.5
Points
PROBABILITY with vig removed
Over 55 Total Points(-115)
51.1%
Under 55 Total Points(-105)
48.9%
LINE MOVEMENT
Pitt
Panthers Injury Report
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Syr
Orange Injury Report
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Pitt
Panthers News
#1 TE
Justin Holmes: Listed as questionable
Oct 16th
Holmes is questionable for Saturday's game against Syracuse.
#1 RB
Desmond Reid: Questionable against Syracuse
Oct 16th
Reid (lower body) has been listed as questionable on Pittsburgh's initial injury report ahead of Saturday's game against Syracuse.
#2 WR
Raphael Williams: Efficient in upset win
Oct 13th
Williams hauled in all six targets for 78 yards during Saturday's 34-31 victory against Florida State.
#2 RB
Ja'Kyrian Turner: Two more TDs
Oct 13th
Turner logged 10 rushes for 44 yards and two touchdowns and gathered in 4 of 5 targets for 34 yards during Saturday's 34-31 win over Florida State.
#1 QB
Mason Heintschel: Leads upset win
Oct 13th
Heintschel was 21-for-29 passing for 321 yards, two touchdowns and two interceptions during Saturday's 34-31 victory against Florida State. He also had 16 rushes for 64 yards.
#4 TE
Adam Howanitz: Staying out vs. FSU
Oct 9th
Howanitz (undisclosed) is out for Saturday's game at Florida State.
#7 RB
Jaylin Brown: Remaining sidelined
Oct 9th
Brown (undisclosed) is inactive for Saturday's game at Florida State.
#6 RB
Synkwan Smith: Out at FSU
Oct 9th
Smith (undisclosed) is out for Saturday's game at Florida State.
#1 WR
Kenny Johnson: Tops 100 yards
Oct 6th
Johnson gathered in 9 of 11 targets for 115 yards and one touchdown during Saturday's 48-7 win against Boston College.
#3 RB
Juelz Goff: 17 carries in big win
Oct 6th
Goff tallied 17 rushes for 59 yards and one touchdown and gathered in 2 of 3 targets for 28 yards during Saturday's 48-7 victory against Boston College.
#2 QB
Eli Holstein: Listed as QB2
Oct 6th
Holstein is listed as a backup quarterback on Pittsburgh's updated depth chart, Stephen Thompson of the Pittsburgh Post-Gazette reports.
Syr
Orange News
#1 TE
Dan Villari: Probable Week 8
Oct 16th
Villari (undisclosed) has been designated as probable ahead of Saturday's game against Pittsburgh.
#1 WR
Johntay Cook: Listed as probable
Oct 16th
Cook is listed as probable for Saturday's game against Pittsburgh.
#2 WR
Justus Ross-Simmons: Deemed questionable
Oct 16th
Ross-Simmons is questionable for Saturday's game against Pitt.
#11 WR
Darius Johnson: Questionable Week 8
Oct 16th
Johnson (leg) has been designated as questionable ahead of Saturday's game against Pittsburgh.
#3 WR
Darrell Gill: Another quiet game
Oct 6th
Gill caught 1 of 3 targets for 13 yards during Saturday's 31-18 defeat versus Southern Methodist.
#1 RB
Yasin Willis: Stifled by SMU
Oct 6th
Willis totaled 15 rushes for 41 yards and gathered in 1 of 2 targets for zero yards during Saturday's 31-18 loss versus Southern Methodist.
#1 QB
Rickie Collins: Three picks in loss
Oct 6th
Collins completed 22 of 45 passes for 279 yards, one touchdown and three interceptions during Saturday's 31-18 defeat against Southern Methodist. He also had 10 rushes for 57 yards with one touchdown.
#2 TE
David Clement: Will play Saturday
Oct 4th
Clement (undisclosed) is off the injury report ahead of Saturday's game against SMU.