NFL Week 13 brings us one of the most loaded slates of the year. We're being treated to three games on Thanksgiving Day, headlined by the Chiefs-Cowboys clash, and another matchup the following day on Black Friday. Then we'll get another 12 games, as there are no byes in Week 13.
Below, our staff broke down everything you need to know about the odds, totals, spreads, and betting lines for Week 13, including a prediction & pick for each game.
Here's a look at our staff's NFL Week 13 moneyline predictions. Make sure to sign up with the best betting apps in the country to tail or fade our picks.
| Matchup | Max | Blake | Tyler | Brandon |
| Packers vs Lions | DET | DET | DET | DET |
| Chiefs vs Cowboys | DAL | KC | KC | KC |
| Bengals vs Ravens | CIN | BAL | BAL | BAL |
| Bears vs Eagles | PHI | CHI | PHI | PHI |
| Rams vs Panthers | LAR | LAR | LAR | LAR |
| 49ers vs Browns | SF | SF | SF | SF |
| Texans vs Colts | HOU | IND | IND | IND |
| Saints vs Dolphins | MIA | MIA | MIA | MIA |
| Falcons vs Jets | ATL | ATL | NYJ | ATL |
| Cardinals vs Buccaneers | TB | AZ | TB | TB |
| Jaguars vs Titans | JAX | JAX | TEN | JAX |
| Vikings vs Seahawks | SEA | SEA | SEA | SEA |
| Raiders vs Chargers | LAC | LAC | LAC | LAC |
| Bills vs Steelers | BUF | BUF | BUF | BUF |
| Broncos vs Commanders | DEN | DEN | DEN | DEN |
| Giants vs Patriots | NE | NE | NE | NE |
There are three NFL games being played on Thanksgiving, 2025. They are featured below:
| Matchup: | Green Bay Packers vs. Detroit Lions |
| Point Spread: | Lions -2.5 |
| Moneyline: | Lions -142 | Packers +120 |
| Over/Under: | 48.5 |
| Date: | Thursday, November 27, 2025 – 1 p.m. EST |
| Location: | Ford Field, Detroit, MI |
| Info Last Verified: | August 13, 2026 |
Detroit could be in trouble here. Green Bay generates pressure at a top-10 rate, and the Packers are also top 10 in sacks (29). Meanwhile, the once-vaunted Lions' offensive line has regressed in a big way, and it's trending in the wrong direction. Jared Goff has taken 14 sacks over the last five games. His only sack-less game in that span came against the toothless Commanders' pass-rush.
When kept clean, Goff is the highest-rated passer in the NFL (128.2), per PFF. When pressured, he ranks 22nd out of 27 qualified passers. That disparity is the key to this game. We saw Green Bay get in his face in the season opener, sacking him four times and holding Detroit to 13 points. Given how Detroit's OL is playing right now, I think we're in for a repeat performance.
| Matchup: | Kansas City Chiefs vs. Dallas Cowboys |
| Point Spread: | Chiefs -3.5 |
| Moneyline: | Chiefs -185 | Cowboys +154 |
| Over/Under: | 52.5 |
| Date: | Thursday, November 27, 2025 – 4:30 p.m. EST |
| Location: | AT&T Stadium, Arlington, TX |
| Info Last Verified: | August 13, 2026 |
Everything I know about football tells me to back the Chiefs in a must-win game. And yet, I can't help myself. I'll take the Cowboys to pull off a Thanksgiving Day stunner. The Chiefs' secondary has been phenomenal all season. But I can't shake the feeling that, aside from the always-excellent Trent McDuffie, this unit is just punching above its weight class. I'm betting that group gets exposed against CeeDee Lamb and the red-hot George Pickens.
I don't think Dallas is suddenly some juggernaut defensively, but I do think that the improvements are for real. With the addition of Quinnen Williams and the return of DeMarvion Overshown, this unit isn't a laughing stock anymore. I think the Cowboys manage to pull out a win in a high-scoring affair here.
| Matchup: | Cincinnati Bengals vs. Baltimore Ravens |
| Point Spread: | Ravens -7.0 |
| Moneyline: | Ravens -355 | Bengals +280 |
| Over/Under: | 51.5 |
| Date: | Thursday, November 27, 2025 – 8:20 p.m. EST |
| Location: | M&T Bank Stadium, Baltimore, MD |
| Info Last Verified: | August 13, 2026 |
Lamar Jackson doesn't look like himself right now. Since returning from injury, he's accounting for nearly 100.0 fewer combined rushing and passing yards per game than he did last season. But a matchup with this Bengals' defense should turn that around. Cincinnati is the league's worst defense in pretty much every metric. Derrick Henry should run wild, and Lamar can do enough as a passer to put this one out of reach. But the looming return of Joe Burrow does introduce some upset potential.
Additionally, there's one Black Friday NFL Game this season. It is featured below:
| Matchup: | Chicago Bears vs. Philadelphia Eagles |
| Point Spread: | Eagles -6.5 |
| Moneyline: | Eagles -305 | Bears +245 |
| Over/Under: | 44.5 |
| Date: | Friday, November 28, 2025 – 3 p.m. EST |
| Location: | Lincoln Financial Field, Philadelphia, PA |
| Info Last Verified: | August 13, 2026 |
Chicago is on a magical 8-1 run since Week 3, but it'll come to a screeching halt on Black Friday. The Bears are a bottom-12 defense in EPA per play, and that unit is trending in the wrong direction. Since Week 9, they're giving up an average of 26.8 PPG. It's not like they've faced a murderer's row of offenses, giving up 42 to Joe Flacco and the Bengals, 17 to the Vikings, 28 to the Aaron Rodgers-less Steelers, and 20 to the Giants, who would've had a much better day had Jaxson Dart not left with a concussion. Coming off a tough loss, I think Philadelphia dominates on both sides of the ball here.
Below, I broke down everything you need to know about the odds and betting lines in this week's slate. All odds in the article are courtesy of bet365 Sportsbook. Be sure to use a bet365 bonus code to maximize your bets.
| Matchup: | Los Angeles Rams vs. Carolina Panthers |
| Point Spread: | Rams -10.0 |
| Moneyline: | Rams -675 | Panthers +490 |
| Over/Under: | 44.5 |
| Date: | Sunday, November 30, 2025 – 1 p.m. EST |
| Location: | Bank of America Stadium, Charlotte, NC |
| Info Last Verified: | August 13, 2026 |
This is the best team in football against Bryce Young. I'll take the best team in football to win, comfortably. Carolina should struggle to move the ball, and the Panthers have no chance at slowing down the Matthew Stafford NFL MVP campaign.
| Matchup: | San Francisco 49ers vs. Cleveland Browns |
| Point Spread: | 49ers -4.5 |
| Moneyline: | 49ers -245 | Browns +200 |
| Over/Under: | 36.5 |
| Date: | Sunday, November 30, 2025 – 1 p.m. EST |
| Location: | Huntington Bank Field, Cleveland, OH |
| Info Last Verified: | August 13, 2026 |
Shedeur Sanders' biggest weakness is an inability to handle pressure. Luckily, he shouldn't face much in Week 13. The 49ers have seven sacks in eight games since losing Nick Bosa, and they're generating pressure at the lowest rate in the league. Ultimately, San Francisco will pull this one out, but Sanders should hit on a few plays that keep this one closer than you might think.
| Matchup: | Houston Texans vs. Indianapolis Colts |
| Point Spread: | Colts -4.5 |
| Moneyline: | Colts -218 | Texans +180 |
| Over/Under: | 44.5 |
| Date: | Sunday, November 30, 2025 – 1 p.m. EST |
| Location: | Lucas Oil Stadium, Indianapolis, IN |
| Info Last Verified: | August 13, 2026 |
This is a must-win game for the Texans. Houston is just two games back of Indianapolis, and these two will face off twice down the stretch. Defensively, the Texans are a nightmare matchup for the Colts. Daniel Jones was sacked just six times in his first seven games, but he's been sacked 15 times over his last four. That's a problem against the Texans, who are tied for the sixth-most sacks in the NFL. They're also more than capable of bottling up Jonathan Taylor, as Houston owns the league's seventh-best run defense EPA. I'll take Houston to win regardless of whose under center in Week 13.
| Matchup: | New Orleans Saints vs. Miami Dolphins |
| Point Spread: | Dolphins -6.0 |
| Moneyline: | Dolphins -265 | Saints +215 |
| Over/Under: | 41.5 |
| Date: | Sunday, November 30, 2025 – 1 p.m. EST |
| Location: | Hard Rock Stadium, Miami Gardens, FL |
| Info Last Verified: | August 13, 2026 |
The Miami Dolphins are kind of rolling right now. They've won three of their last four, putting up at least 30 points twice in that span. The Saints' defense is a lot better than you might think, but with the way De'Von Achane and Jaylen Waddle are playing right now, I don't think New Orleans has the firepower to keep pace on the road.
| Matchup: | Atlanta Falcons vs. New York Jets |
| Point Spread: | Falcons -2.5 |
| Moneyline: | Falcons -148 | Jets +124 |
| Over/Under: | 39.5 |
| Date: | Sunday, November 30, 2025 – 1 p.m. EST |
| Location: | MetLife Stadium, East Rutherford, NJ |
| Info Last Verified: | August 13, 2026 |
Don't look now, but with some uncertainty surrounding Baker Mayfield's status, the Atlanta Falcons aren't totally dead in the NFC South just yet. Atlanta's pass-rush is on fire, recording 20 sacks over its last four games. The Falcons are now third in sacks on the season (39). Tyrod Taylor won't have a chance against this young pass-rush, and NYJ will struggle to contain Bijan Robinson.
| Matchup: | Arizona Cardinals vs. Tampa Bay Buccaneers |
| Point Spread: | Buccaneers -3.0 |
| Moneyline: | Buccaneers -155 | Cardinals +130 |
| Over/Under: | 44.5 |
| Date: | Sunday, November 30, 2025 – 1 p.m. EST |
| Location: | Raymond James Stadium, Tampa, FL |
| Info Last Verified: | August 13, 2026 |
The Buccaneers' season looked so promising to begin the year, but that has all come to a screeching halt. Baker Mayfield has been held under 230 passing yards in four of his last five outings – something he only did twice over his first six. And it's not clear if he'll even be able to play. If Teddy Bridgewater is under center, Tampa Bay has no shot at keeping pace with a scrappy Cardinals team. But the Jacoby Brissett-led Cardinals should be able to keep this one close even if Mayfield does suit up.
| Matchup: | Jacksonville Jaguars vs. Tennessee Titans |
| Point Spread: | Jaguars -6.5 |
| Moneyline: | Jaguars -285 | Titans +230 |
| Over/Under: | 41.5 |
| Date: | Sunday, November 30, 2025 – 1 p.m. EST |
| Location: | Nissan Stadium, Nashville, TN |
| Info Last Verified: | August 13, 2026 |
The Jacksonville Jaguars are 7-4 despite the fact that they don't really do anything well. But they should have no trouble improving to 8-4. Cam Ward finally showed some signs of life in Week 12, throwing for 254 yards with one touchdown and no INTs against the dominant Seahawks' defense. But the rest of the roster is just flat-out overmatched here. I'll take Jacksonville to win, but I'd look out for Ward to lead a backdoor cover.
| Matchup: | Minnesota Vikings vs. Seattle Seahawks |
| Point Spread: | Seahawks -11.5 |
| Moneyline: | Seahawks -700 | Vikings +500 |
| Over/Under: | 41.5 |
| Date: | Sunday, November 30, 2025 – 4:05 p.m. EST |
| Location: | Lumen Field, Seattle, WA |
| Info Last Verified: | August 13, 2026 |
This might be the last game we see with J.J. McCarthy under center for Minnesota in 2025. He has no chance against Seattle. The Seahawks generate pressure at the fifth-highest rate in the league and have racked up the fourth-most sacks. McCarthy has the fourth-worst passer rating in the league when pressured, per PFF. Even if, by some miracle, Minnesota does manage to keep him clean, it won't matter. When kept clean, McCarthy has the lowest passer rating (62.7) among all QBs with at least 40 dropbacks. This one will get ugly fast.
| Matchup: | Las Vegas Raiders vs. Los Angeles Chargers |
| Point Spread: | Chargers -10.0 |
| Moneyline: | Chargers -600 | Raiders +440 |
| Over/Under: | 41.5 |
| Date: | Sunday, November 30, 2025 – 4:25 p.m. EST |
| Location: | SoFi Stadium, Inglewood, CA |
| Info Last Verified: | August 13, 2026 |
The Chargers had strung together three solid wins before suffering a 35-7 beatdown to the Jacksonville Jaguars in Week 11. Their Week 12 bye couldn't have come at a better time. LAC should be a lot healthier in Week 13, and I think that makes all the difference. My only concern is a potential spike from the Raiders' offense now that Chip Kelly is gone, but LV's offensive line is not good enough for that to matter.
| Matchup: | Buffalo Bills vs. Pittsburgh Steelers |
| Point Spread: | Bills -3.5 |
| Moneyline: | Bills -185 | Steelers +154 |
| Over/Under: | 47.5 |
| Date: | Sunday, November 30, 2025 – 4:25 p.m. EST |
| Location: | Acrisure Stadium, Pittsburgh, PA |
| Info Last Verified: | August 13, 2026 |
The Bills need a get-right game, and the Steelers are about as good a matchup as Buffalo could hope for. Pittsburgh owns the league's sixth-worst run defense in EPA. They're better against the pass, but the only thing they do at a high level is rush the passer, and the Bills have one of the best offensive lines in football (the Week 12 game notwithstanding). James Cook and Josh Allen should dominate on the ground, leading Buffalo to a much-needed win.
| Matchup: | Denver Broncos vs. Washington Commanders |
| Point Spread: | Broncos -6.5 |
| Moneyline: | Broncos -310 | Commanders +250 |
| Over/Under: | 43.5 |
| Date: | Sunday, November 30, 2025 – 8:20 p.m. EST |
| Location: | Northwest Stadium, Landover, MD |
| Info Last Verified: | August 13, 2026 |
The Denver Broncos are going to dominate the Washington Commanders. Denver generates the most pressure in the league, and as a result, the Broncos also lead the league in sacks (49). Even if Jayden Daniels manages to return in Week 13, this pass-rush is too much for Washington to handle.
| Matchup: | New York Giants vs. New England Patriots |
| Point Spread: | Patriots -7.0 |
| Moneyline: | Patriots -395 | Giants +310 |
| Over/Under: | 46.5 |
| Date: | Monday, December 1, 2025 – 8:15 p.m. EST |
| Location: | Gillette Stadium, Foxborough, MA |
| Info Last Verified: | August 13, 2026 |
This game will be much closer than any matchup between two teams with an eight-win gap should be. The 2-10 New York Giants don't do a whole lot well, but they are a scary pass-rush, grading out as a top-12 unit, per PFF. New England's offensive line, meanwhile, was really just an average unit at its best, and now it looks like it'll be without its entire starting left side. I wouldn't be totally shocked if NYG won, but I'll bet that Drake Maye does just enough to win a game that comes down to the wire.
There are no NFL teams on bye in Week 13.