Brandon Aiyuk headshot

Brandon Aiyuk Injury: May have practice window opened soon

Written by RotoWire Staff

Published on October 24, 2025

Coach Kyle Shanahan said Friday that the 49ers may designate Aiyuk (knee) to return from the reserve/PUP list next week, David Lombardi of SFStandard.com reports.

Aiyuk is a shade more than one year removed from tearing the ACL and MCL in his right knee Week 7 of last season. Once the 49ers make the aforementioned transaction, be it next week or beyond that point, the team will have a 21-day window in which to evaluate Aiyuk in practice to determine his return to action. Shanahan added that San Francisco currently is in "week-to-week mode" with Aiyuk, meaning he may need a few weeks to get up to speed before gaining clearance to play.

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