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Best Bets for San Francisco 49ers vs. Tampa Bay Buccaneers | San Francisco 49ers +3.0 (+100)
Mac Jones will look to extend his high-quality play as San Francisco's quarterback on the road against the 4-1 Tampa Bay Buccaneers today. As a starter, Jones is 3-0, beating the Rams with over 340 passing yards in Week 5.
NFL fans can claim the current DraftKings Promo Code to get $200 in bonus bets instantly with the San Francisco 49ers vs. Tampa Bay Buccaneers set for kickoff this afternoon. Place a $5 qualifying wager on any sport to get $200 in bonus bets, win or lose!
Oddsmakers value the Buccaneers as a -3 point favorite at home against San Francisco. The 49ers are dealing with a ton of injuries, however, they've been able to stack wins and enter this matchup with a 4-1 record atop the NFC West.
The point total is set to 47.5. The 49ers' defense is not the same without star edge rusher Nick Bosa, allowing over 320 yards of offense in back-to-back games against the Jaguars and Rams.
Baker Mayfield has been electrifying as Tampa Bay's quarterback in 2025. He's led the offense on multiple game-winning drives and has built a great rapport with first-round rookie wideout Emeka Egbuka.
The Buccaneers are coming off a gritty 38-35 road win over Seattle in Week 5. San Francisco has just as much momentum, plus a few extra days' rest, following their overtime win against the Los Angeles Rams on Thursday Night Football.
Tampa Bay's only loss this season came at home against the Eagles. Their pass defense is porous, allowing 341 passing yards to Sam Darnold in Week 5. Jones, despite having a banged-up wide receiving corps, is dealing from the pocket right now.
Let's take San Francisco +3 on the road to keep this game tight and within a field-goal deficit by the final whistle at even odds.
Best Bets for San Francisco 49ers vs. Tampa Bay Buccaneers | O 47.5 (-110)
Both San Francisco and Tampa Bay have been profitable on the point total over at 3-2 in 2025. The 49ers have scored 21 or more points in three of their last four games, while Tampa Bay has allowed 27 points in three straight matchups.
Bosa's absence means Mayfield won't feel nearly as pressured in the pocket. Factor in young playmakers like RB Bucky Irving and Egbuka, plus the return of WR Chris Godwin, and it feels like the wrong total is favored.
Let's bet over 47.5 total points at -110 odds. Both offenses will continue to find ways to get into the end zone, despite dealing with injuries to a few star players.
Best Bets for San Francisco 49ers vs. Tampa Bay Buccaneers | Jake Tonges Anytime Touchdown Scorer (+285)
George Kittle's injury has allowed San Francisco TE Jake Tonges to slot in as the team's top tight end target within Kyle Shanahan's offense. As a result, Tonges has been heavily involved, recording seven receptions for 43 yards and a touchdown on 11 targets against Los Angeles last week.
Tampa Bay has been terrible at containing tight ends in the red zone. The Buccaneers have allowed four touchdowns to tight ends in two straight games. In fact, both tight ends, Dallas Goedert and AJ Barner, scored twice against Tampa Bay.
Tonges' target volume with Jones is elevated due to injuries in the wide receiving corps. Factor in a soft matchup against a pedestrian Buccaneers secondary, and Tonges' +285 odds to score a touchdown for the second straight week stands out as a high-value pick.
San Francisco 49ers vs. Tampa Bay Buccaneers Picks
- San Francisco 49ers +3.0 (+100)
- O 47.5 (-110)
- Jake Tonges Anytime Touchdown Scorer (+285)
Best Events to Use the DraftKings Promo Code For on October 12th
- NFL: Arizona Cardinals vs. Indianapolis Colts. The red-hot Colts host a Cardinals team that has lost three straight games. Indianapolis is a -7 point favorite with a 46.5 point total.
- NFL: Los Angeles Chargers vs. Miami Dolphins. Justin Herbert and the Chargers will look to regroup after losing two straight games. Los Angeles is a -4.5 point favorite on the road against a one-win Dolphins team, with a 44.5 point total.
- MLB: ALCS Game 1 matchup between the Detroit Tigers/Seattle Mariners vs. Toronto Blue Jays.
- NHL: Washington Capitals vs. New York Rangers. The standalone NHL game on Sunday's slate with both Metropolitan Division opponents dropping their first game of the 2025-26 season.
