Biyombo appeared in 53 games for the Hornets during the 2019-20 season. He averaged a career-high 7.4 points, 5.8 rebounds, 0.9 assists, 0.9 blocks and 0.2 steals across 19.4 minutes per game. He shot 54.3 percent from the field and 60.3 percent from the free-throw line. Biyombo set single-game season highs of 19 points, 17 rebounds, four assists, four blocks and two steals. His 19-point effort was arguably his best overall performance of the season, and it occurred Nov. 27 against the Pistons. He shot 8-of-11 from the field and 3-of-5 from the charity stripe while also posting nine rebounds (three offensive), two blocks and one assist with no turnovers in 34 minutes. Biyombo had 22 games with double-digit points, nine games with double-digit rebounds and 14 games with multiple assists. He also had nine games with at least one steal and 29 games with at least one block. Biyombo racked up eight double-doubles. During the six games in which Biyombo saw 30-plus minutes, he averaged 12.0 points, 9.0 rebounds, 1.7 blocks and 1.5 assists.

After two seasons in Orlando, Biyombo returned to Charlotte in 2018. Though he only missed one game in three seasons prior to 2018, Biyombo was a bit beset by injury during the 2018-19 season. A nagging knee issue made him miss several games, including a stretch where he missed 18 of 20 games. Biyombo ended up playing in 54 games, starting 32 of them. Those 54 games were the smallest season total over his eight year career. He played 14.5 minutes per game and took 2.9 shots per contest. The 6-foot-9 big man ended up averaging 4.4 points per game. The one-time seventh-overall pick also put up 4.6 boards a night. Biyombo had two games in which he blocked five shots. In one of those games, Biyombo had arguably his best outing of the season. In a late January win over the Suns, the center picked up 13 points and 11 rebounds to go with those blocks. Biyombo also produced a 16-point, 12-rebound gem during a January loss to the Nuggets.

2017-2018 marked Biyombo's second season with the Magic and seventh in the NBA. He played in all 82 games and started 25. He would go on to post averages of 5.7 points and 5.7 rebounds. Biyombo shot 52 percent from the field, his fifth-straight season notching over 50 percent in that category. He also connected on a career-best 65 percent from the foul line. Biyombo notched seven double-doubles during the regular season. He'd set a career-high with 21 points at Washington on Jan .12. In that contest, Biyombo went 8-of-9 from the floor and 5-of-6 from the charity stripe. He also snatched a season-high 17 rebounds at Brooklyn on New Year's Day. Biyombo did his best work in January by registering 8.5 points, 8.6 rebounds, 1.3 assists and 1.8 rejections per contest. He finished the season by blocking 95 shots, ranking him 19th in the league.

During July of 2016, Biyombo signed a four-year contract with the Magic. Under head coach Frank Vogel, he appeared in all but one game during the 2016-17 campaign while also drawing 27 starts. Biyombo set a career high with 6.0 points per game while shooting 52.8 percent from the field and 53.4 percent from the free-throw line. He also averaged 7.0 rebounds and 1.1 blocks across 22.1 minutes. Biyombo also set new per-100-possession career highs in points (13.4) and assists (2.0). In the NBA ranks, Biyombo was 20th in total rebound percentage (17.2) and 14th in block percentage (4.1). He set single-game season highs with 15 points, 15 rebounds, five blocks, four assists and two steals. Arguably Biyombo's best performance of the campaign occurred Feb. 11 against Dallas, when he posted 15 points, seven rebounds, two assists, a steal and a block in 21 minutes. He chipped in 10 double-doubles over the course of the year, as well.

During July of 2015, Biyombo signed a contract with the Raptors. He proceeded to play in all 82 games for the first time in his career, and he also drew 22 starts. In 22.0 minutes per game, Biyombo set career highs in points (5.5), rebounds (8.0) and free-throw percentage (62.8). He also averaged 1.6 blocks and shot 54.2 percent from the field. Biyombo set new single-game career highs in points (16) and rebounds (25). His other single-game season highs stood at seven blocks, two steals and two assists. Biyombo also pitched in nine double-doubles. Under head coach Dwane Casey, the Raptors finished the campaign 56-26, making the playoffs. The Raptors lost to the Cavaliers in the Eastern Conference Finals after defeating the Heat in the Conference Semifinals and the Pacers in the Conference First Round. In the postseason, Biyombo appeared in all 20 games, averaging 6.2 points, 9.4 rebounds and 1.4 blocks across 25.3 minutes.

Under head coach Steve Clifford, Biyombo appeared in 64 games (21 starts) for the Hornets during the 2014-15 season. As a reserve, he averaged 3.7 points, 5.4 rebounds and 1.4 blocks across 15.8 minutes per game. As a starter, he averaged 6.8 points, 8.4 rebounds and 1.8 blocks across 26.9 minutes per contest. Overall, he shot 54.3 percent from the field and a career-high 58.3 percent from the charity stripe. Biyombo's 1.5 blocks per game ranked 17th in the NBA. He set new per-100-possession career highs in points (12.6), offensive rebounds (6.6) and free-throw attempts (7.3). On Nov. 21, Biyombo swatted a season-best six shots in a home loss to the Magic. On Jan. 10, the center scored a career-best-matching 14 points, plus added 12 boards, during a win at New York. Four nights later he grabbed a season-high 15 rebounds, plus scored 12 points, in a home loss to the Spurs. Arguably his best performance of the season occurred Apr. 7 during a loss at Miami. Biyombo played 41 minutes and posted 12 points (4-6 FG, 4-6 FT), 12 rebounds, four blocks, two steals and two assists.

Biyombo appeared in 77 games (nine starts) for the Bobcats during the 2013-14 season. He saw 13.9 minutes per game and averaged 2.9 points on a career-high 61.1 percent shooting from the field. He also averaged 4.8 rebounds and 1.1 blocks per contest. As a starter, Biyombo averaged 4.7 points, 8.2 rebounds and 1.3 blocks across 27.0 minutes per start. Biyombo set single-game season highs of 11 points, 14 rebounds, five blocks, one steal and one assist. On Nov. 11, Biyombo started and delivered a season-high 11 points, plus 10 rebounds and two blocks during a home win over the Cavaliers. On Nov. 29, the big center grabbed a season-high 14 rebounds during a home win over the Bucks. During a Feb. 19 win over the Pistons, Biyombo swatted a season-high five blocks and grabbed eight rebounds during 13 minutes of run. The Bobcats finished the campaign 43-39, making the playoffs under head coach Steve Clifford. Charlotte lost in the Eastern Conference First Round to Miami. Biyombo appeared in three of Charlotte's four postseason contests and averaged 2.7 points and 3.7 rebounds per game. His best effort in the series occurred during Game 4, where he drew the start and posted seven points (3-5 FG, 1-4 FT), eight rebounds and one assist in 33 minutes.

Biyombo appeared in 80 games (65 starts) for the Bobcats during the 2012-13 season, his second in the Association. Under head coach Mike Dunlap, he saw 27.3 minutes per game and averaged 4.8 points on 45.1 percent shooting from the field. He also averaged a career-high 7.3 rebounds per game and again blocked 1.8 shots per game. Biyombo set a new single-game career high with 17 rebounds on Jan. 6 during a win over the Pistons, and he tied that mark again on Apr. 13 in a win over the Bucks. Biyombo's best game of the season occurred Dec. 21 versus the Warriors, where he posted 12 points (4-6 FG, 4-4 FT), 14 rebounds, two blocks, one assist and one steal in 32 minutes. That game marked one of his seven double-doubles for the season.

Following one season playing in the Spanish ACB, Biyombo was selected by Charlotte with the seventh overall pick in the 2011 NBA Draft. He made his NBA debut for Bobcats during the first game of the lockout-shortened season, Dec. 26, in a one-point win over the Bucks. He saw six minutes and committed one turnover. Biyombo ultimately played in 63 of a possible 66 games, drawing 41 starts. Under coach Paul Silas, Biyombo saw 23.1 minutes per game, averaging 5.2 points on 46.4 percent shooting from the field. I also generated 5.8 rebounds and 1.8 blocks per contest. On Mar. 6, the rookie grabbed a season-high 15 rebounds, plus added 10 points and a season-best seven blocks, during a home win over the Magic. The big center recorded five double-doubles for the season and twice blocked seven shots in a game. On Apr. 6, the rookie started and scored a season-high 14 points to go with 14 rebounds during a loss at Milwaukee.