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Seahawks vs 49ers Odds, Lines, Spreads & Totals 2025

49ers
Seahawks
Sunday September 7, 2025 at 4:05 PM ET
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SF
49ers Injury Report
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SEA
Seahawks Injury Report
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SF
49ers Lineup
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SEA
Seahawks Lineup
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SF
49ers News
#2 WR
Ricky Pearsall: Leads team with 108 receiving yards
Sep 7th
Pearsall brought in four of seven targets for 108 yards in Sunday's 17-13 win over Seattle.
#2 K
Jake Moody: Struggles in Week 1
Sep 7th
Moody went 1-for-3 on field-goal tries and 2-for-2 on PATs in Sunday's 17-13 win over the Seahawks.
#1 QB
Brock Purdy: Finishes strong to earn win
Sep 7th
Purdy completed 26 of 35 pass attempts for 277 yards, two touchdowns and two interceptions while taking five carries for 17 yards in Sunday's 17-13 win over the Seahawks.
#1 WR
Jauan Jennings: Will get MRI on shoulder
Sep 7th
Jennings (shoulder) will have an MRI within the next 24 hours to determine the severity of his injury, Nick Wagoner of ESPN.com reports.
#4 TE
George Kittle: Set for MRI on hamstring
Sep 7th
Kittle (hamstring) will have an MRI within the next 24 hours to determine the severity of his injury, Nick Wagoner of ESPN.com reports.
#1 RB
Christian McCaffrey: Racks up 142 yards from scrimmage
Sep 7th
McCaffrey (calf) handled 22 carries for 69 yards and nine receptions for 73 yards on 10 targets in Sunday's 17-13 win over the Seahawks.
#7 WR
Jordan Watkins: Not playing Week 1
Sep 7th
Watkins (ankle) has been ruled out for Sunday's game against the Seahawks.
#4 RB
Jordan James: Not playing vs. Seattle
Sep 7th
James (finger) is inactive for Sunday's game against the Seahawks.
#1 FS
Marques Sigle: Gets starting nod Week 1
Sep 7th
Sigle will be the 49ers' starting safety against the Seahawks on Sunday, Matt Maiocco of NBC Sports Bay Area reports.
#1 RG
Dominick Puni: Ready to face Seahawks
Sep 5th
Puni (knee) does not have an injury designation ahead of Sunday's game against the Seahawks, Michael-Shawn Dugar of The Athletic reports.
#2 LDE
Yetur Gross-Matos: Cleared for Week 1
Sep 5th
Gross-Matos (knee) does not have an injury designation ahead of Sunday's game against the Seahawks, Michael-Shawn Dugar of The Athletic reports.
#2 LG
Ben Bartch: Full practice Wednesday
Sep 3rd
Bartch (elbow) was a full participant at the 49ers' practice Wednesday, Cam Inman of The San Jose Mercury News reports.
#2 RDE
Sam Okuayinonu: Logs full practice Wednesday
Sep 3rd
Okuayinonu (shoulder) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#2 DT2
CJ West: Logs full practice Wednesday
Sep 3rd
West (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 SCB
Upton Stout: Recovered from calf injury
Sep 3rd
Stout (calf) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 RDE
Mykel Williams: Full participant in practice
Sep 3rd
Williams (knee) practiced in full Wednesday, Cam Inman of The San Jose Mercury News reports.
#2 SS
Jason Pinnock: Logs full practice
Sep 3rd
Pinnock (heel) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#1 RCB
Deommodore Lenoir: Recovered from hip injury
Sep 3rd
Lenoir (hip) was not listed on the 49er's injury report Wednesday, Cam Inman of The San Jose Mercury News reports.
#3 RDE
Nick Bosa: Fades injury report
Sep 3rd
Bosa (neck) was not listed on Wednesday's injury report, Cam Inman of The San Jose Mercury News reports.
#2 QB
Mac Jones: Past knee injury
Sep 3rd
Jones (knee) was a full participant in Wednesday's practice, Cam Inman of The San Jose Mercury News reports.
#3 RB
Isaac Guerendo: Full practice Wednesday
Sep 3rd
Guerendo (shoulder) practiced fully Wednesday, Cam Inman of The San Jose Mercury News reports.
#4 WR
Marquez Valdes-Scantling: Signed to active roster
Sep 2nd
The 49ers signed Valdes-Scantling to the active roster from the practice squad Tuesday, Aaron Wilson of KPRC 2 Houston reports.
#3 RCB
Jakob Robinson: Moves to IR
Aug 27th
Robinson (forearm) was placed on injured reserve Tuesday.
#9 WR
Jacob Cowing: Lands on injured reserve
Aug 27th
The 49ers placed Cowing (hamstring) on injured reserve Wednesday.
#3 LDT
Kevin Givens: Heads to IR
Aug 26th
Givens (pectoral) was placed on injured reserve Tuesday.
#2 FS
Malik Mustapha: Lands on PUP list
Aug 26th
Mustapha (knee) was placed on the reserve/PUP list Tuesday.
#4 QB
Kurtis Rourke: Shifts to NFI list
Aug 26th
Rourke (knee) was placed on the reserve/non-football injury list Tuesday.
#8 WR
Brandon Aiyuk: Shifts to reserve/PUP list
Aug 26th
The 49ers moved Aiyuk (knee) to the reserve/PUP list Tuesday.
SEA
Seahawks News
#2 WR
Cooper Kupp: Non-factor in SEA debut
Sep 7th
Kupp brought in two of three targets for 15 yards in Sunday's 17-13 loss to the 49ers.
#2 RB
Zach Charbonnet: Leads backfield in Week 1 loss
Sep 7th
Charbonnet took 12 carries for 47 yards and a touchdown in Sunday's 17-13 loss to the 49ers.
#1 RB
Kenneth Walker: Splits backfield work Sunday
Sep 7th
Walker took 10 carries for 20 yards while bringing in all three of his targets for four yards in Sunday's 17-13 loss to San Francisco.
#1 QB
Sam Darnold: Mediocre debut with SEA
Sep 7th
Darnold completed 16 of 23 pass attempts for 150 yards with a fumble lost while rushing twice for 14 yards in Sunday's 17-13 loss to the 49ers.
#1 K
Jason Myers: Makes both FGs in loss
Sep 7th
Myers went 2-for-2 on field-goal attempts and made his lone extra-point try in Seattle's 17-13 loss to the 49ers on Sunday.
#1 WR
Jaxon Smith-Njigba: Leading receiver in losing effort
Sep 7th
Smith-Njigba finished with nine receptions on 13 targets for 124 yards with a lost fumble in Sunday's 17-13 loss to San Francisco.
#2 SS
Nick Emmanwori: Returns Sunday
Sep 7th
Emmanwori (ankle) has returned for Sunday's game against the 49ers, Curtis Crabtree of Fox 13 Seattle reports.
#4 TE
Nick Kallerup: Won't make NFL debut Week 1
Sep 7th
Kallerup (coach's decision) is inactive for Sunday's tilt against San Francisco.
#5 WR
Dareke Young: Out for Sunday
Sep 5th
Young (hamstring) won't play in Sunday's matchup against the 49ers, Brady Henderson of ESPN.com reports.
#2 SLB
Uchenna Nwosu: Missing Week 1
Sep 5th
Nwosu (knee) has been ruled out ahead of Sunday's contest against the 49ers, Brady Henderson of ESPN.com reports.
#1 SCB
Riq Woolen: Past illness
Sep 5th
Woolen (illness) carries no injury designation into Sunday's game against the 49ers, Brady Henderson of ESPN.com reports.
#4 WR
Jake Bobo: Doesn't clear protocol for Week 1
Sep 5th
Bobo (concussion) has been ruled out for Sunday's game against the 49ers, John Boyle of the Seahawks' official site reports.
#1 RG
Anthony Bradford: Ready to rock
Sep 5th
Bradford (back) has no injury designation ahead of Sunday's matchup against the 49ers, Brady Henderson of ESPN.com reports.
#1 RT
Abraham Lucas: Nabs extension from Seattle
Sep 4th
Lucas and the Seahawks agreed Thursday on a three-year, $46 million contract extension, Mike Garafolo of NFL Network reports.
#2 RDE
Mike Morris: Not listed on injury report
Sep 3rd
Morris (concussion) wasn't listed on Seattle's injury report Wednesday, John Boyle of the team's official site reports.
#1 LT
Charles Cross: Taken off injury report
Sep 3rd
Cross (finger) wasn't listed on Seattle's injury report Wednesday, John Boyle of the team's official site reports.
#2 LILB
Tyrice Knight: Not listed on injury report
Sep 3rd
Knight (knee) wasn't listed on Seattle's injury report Wednesday, John Boyle of the team's official site reports.
#3 WR
Tory Horton: Logs full practice Wednesday
Sep 3rd
Horton (ankle) was a full practice participant Wednesday, John Boyle of the Seahawks' official site reports.
#2 RILB
Chazz Surratt: Joins Seahawks
Aug 28th
Surratt signed with the Seahawks on Thursday.
#2 RG
Christian Haynes: Placed on IR, designated to return
Aug 27th
Haynes (pectoral) was placed on injured reserve with a designation to return Tuesday, John Boyle of the Seahawks' official website reports.
#2 SCB
Derion Kendrick: Headed to Seattle
Aug 27th
Kendrick was claimed off waivers by the Seahawks on Wednesday, John Boyle of the team's official website reports.
#3 RDE
Rylie Mills: Starting career on NFI list
Aug 27th
Mills (knee) was moved to the reserve/non-football injury list Tuesday, John Boyle of the Seahawks' official site reports.
#3 NT
Johnathan Hankins: Starting season on NFI list
Aug 27th
Hankins (back) was moved to the reserve/non-football injury list Tuesday, John Boyle of the Seahawks' official site reports.
#3 RB
George Holani: Secures No. 3 job
Aug 27th
Holani was named the No. 3 running back after the Seahawks waived Damien Martinez on Tuesday, Michael-Shawn Dugar of The Athletic reports.
#2 NT
Brandon Pili: Dealing with undisclosed injury
Aug 25th
Pili (undisclosed) is uncertain to play in Week 1 versus the 49ers, Brady Henderson of ESPN.com reports.
#3 QB
Jalen Milroe: Will get special package of plays
Aug 25th
Milroe will have a special set of plays installed in Seattle's offense for regular-season games, Bob Condotta of The Seattle Times reports.