The four teams in Group H will finally make their World Cup debuts Tuesday, while Russia and Egypt will battle it out for second place in Group A.
Uruguay are significant favorites to win Group A, but the bigger story line will be whether Russia can avoid being just the second host nation to not reach the knockout rounds.
Arsenal will try to book their ticket to the Europa League semifinals Thursday at CSKA Moscow, with a win or draw automatically seeing them through.
Arsenal will be without Pierre-Emerick Aubameyang on Thursday against CSKA Moscow, which will leave Alexandre Lacazette to spearhead the attack.
Arsenal picked up two important away goals in the first leg, and they'll look to finish off AC Milan at the Emirates on Thursday.
Atletico Madrid are the biggest favorites and have the highest implied goal total on Thursday's early Europa League slate, which means many eyes will be on Antoine Griezmann.
Miralem Pjanic's role for Juventus allows him to pick up fantasy points all over the pitch, giving him a solid floor Wednesday against Olympiacos.
Manchester United are big favorites against FC Basel on Tuesday's eight-game Champions League slate, and the oddsmakers are expecting Romelu Lukaku to find the back of the net.
Juventus are big favorites Tuesday against Dinamo Zagreb, which puts Paulo Dybala firmly in play because of his solid fantasy floor.
With Cristiano Ronaldo on the docket, fantasy owners will need to figure out a way to fit in his enormous salary. Luckily, Alex Spalding is here to help.