Jozy Altidore has returned to Toronto FC after being dropped from the USMNT Gold Cup roster, but a number of key MLS players won't play this weekend.
New York City FC's David Villa leads the goal expectancy list this week, and he's one of only two players projected to take at least five shots, with two on goal.
A few big name players are out with injuries, while the Gold Cup has taken a few more top stars like Toronto's Jozy Altidore.
RotoWire's JD Bazzo thinks it's a good idea to target Chicago Fire players against Real Salt Lake, and Harry Shipp fits right into the plan.
Clint Dempsey leads JD Bazzo's top midfielders for the upcoming season.
Yaya Toure suffered an ankle injury in Wednesday's FA Cup rout of West Ham, and he faces a late fitness test ahead of Sunday's match at Newcastle.
Robin van Persie could make his return after battling a thigh injury for most of December.
Aaron Ramsey suffered a thigh strain against West Ham on Boxing Day, and will now miss the remainder of the holiday period.
Christian Benteke has been ruled out for the entire holiday period due to the knee injury he's been playing through over the past month.
Sergio Aguero is expected to miss at least a month due to the calf injury he suffered in last weekend's tilt with Arsenal.
Robin van Persie was a surprise member of Manchester United's starting XI last week, but suffered an injury in the Champions League on Tuesday and will now be out a month.
Robin van Persie has missed four games in a row and doesn't appear ready for this weekend's match against Newcastle.
Vincent Kompany has been deemed fit and is expected to start Wednesday against West Brom.
Vincent Kompany was held out of Manchester City's Champions League clash against Viktoria Plzen on Wednesday but looks set to return this weekend.
Theo Walcott looks set to return for Arsenal's important match against surprising Southampton on Saturday.
Vincent Kompany's thigh injury will keep him out again.