Christian Benteke ruptured his Achilles tendon during Thursday's training session and he will now miss the rest of the Premier League season and the World Cup.
Aaron Ramsey suffered yet another setback and he'll be sidelined for at least another two weeks.
Eden Hazard picked up an ankle injury while on international duty Wednesday, but he is expected to be fit to face Tottenham this weekend.
Romelu Lukaku will get an extra week off to recover from his ankle injury, as he's ineligible to play against his parent club this weekend.
Aaron Ramsey suffered a setback in his recovery from a thigh injury and will miss out yet again.
After finishing up a warm-weather training trip in Egypt, Wayne Rooney looks set to return to a Manchester United side that will also include newly-signed Juan Mata.
Sergio Aguero is expected to miss at least a month due to the calf injury he suffered in last weekend's tilt with Arsenal.
Robin van Persie was a surprise member of Manchester United's starting XI last week, but suffered an injury in the Champions League on Tuesday and will now be out a month.