Sergio Aguero is expected to miss at least a month due to the calf injury he suffered in last weekend's tilt with Arsenal.
Robin van Persie has missed four games in a row and doesn't appear ready for this weekend's match against Newcastle.
Vincent Kompany was held out of Manchester City's Champions League clash against Viktoria Plzen on Wednesday but looks set to return this weekend.
Theo Walcott looks set to return for Arsenal's important match against surprising Southampton on Saturday.