With Kevin De Bruyne possibly missing out due to injury, David Silva's attacking responsibilities grow, as does his fantasy upside against West Brom.
Zlatan Ibrahimovic has some of the best odds to score a goal this weekend, as he'll face off against a Burnley side that have allowed the second-most shots and shots on target this season.
With FanDuel introducing English Premier League contests this week, RotoWire's Andrew Laird looks into the key stats to focus on when building lineups.
Bradley Wright-Phillips has an excellent matchup Sunday as the Red Bulls try to get closer to clinching the Supporters Shield, but is he worth fading in Sunday DraftKings lineups?
Obafemi Martins is easily the top play Saturday, but you'll need more than the Sounders striker to win a tournament. JD Bazzo breaks down the best fantasy teammates to help players on DraftKings cash on Saturday.
RotoWire's JD Bazzo thinks Obafemi Martins is one of the top plays this weekend, and he has a few different ways to comfortably get the Sounders attacker into DraftKings lineups with some other upper-tier players.
Sebastian Giovinco has gone back-to-back games without a goal, but a home match against Orlando City keeps him at the top of the forwards rankings.
Mauro Diaz is questionable for Saturday's match at Vancouver because of a quad injury that held him out last weekend. D.J. Trainor breaks down the other injury news heading into the weekend.
David Villa faces off against one of the tougher defenses in Major League Soccer, but he's still the top forward on the early slate.
Andrew Laird and JD Bazzo go head-to-head in this week's fantasy MLS rankings, though neither can go against putting Sebastian Giovinco on the top of the forwards list.
Only days after taking home the MLS All-Star Game Most Valuable Player Award, Kaka is the unanimous top pick for fantasy midfielders this weekend.
David Villa has six goals in his last four games and will next face off against a Montreal side he's burned for three goals and one assist in two previous meetings.
David Villa is high up on the goal expectancy projection for Week 22, though there are a few players with better chances.
The Sounders could be getting a number of players back from the Gold Cup this weekend, but Obafemi Martins remains sidelined with a groin injury.
Jozy Altidore has returned to Toronto FC after being dropped from the USMNT Gold Cup roster, but a number of key MLS players won't play this weekend.
RotoWire's JD Bazzo breaks down his top plays on DraftKings this weekend, including Kei Kamara, who is the cheapest of the three elite forwards on the Saturday slate.
A few big name players are out with injuries, while the Gold Cup has taken a few more top stars like Toronto's Jozy Altidore.
A number of star players have already met up with their international teams for the Gold Cup, while a few others are sidelined with injuries.