Kei Kamara is tied with Sebastian Giovinco for the MLS goal lead, but the Crew striker is unavailable this weekend due to yellow card accumulation.
Orlando City continues to fight for a playoff spot, but they'll face off against New York City FC this weekend without Kaka, who is suspended for the match.
RotoWire's D.J. Trainor breaks down the latest injury news ahead of Major League Soccer's two-game Wednesday slate of games.
David Villa has six goals in his last four games and will next face off against a Montreal side he's burned for three goals and one assist in two previous meetings.
David Villa is high up on the goal expectancy projection for Week 22, though there are a few players with better chances.