Kei Kamara is tied with Sebastian Giovinco for the MLS goal lead, but the Crew striker is unavailable this weekend due to yellow card accumulation.
Orlando City continues to fight for a playoff spot, but they'll face off against New York City FC this weekend without Kaka, who is suspended for the match.
Sebastian Giovinco was slated to play for Italy over the international break, which MLS plays through, but an adductor injury will keep him on the sidelines.
Kaka was a surprise absence Wednesday against Toronto, but he has stated that he will play Saturday against Philadelphia.
Sebastian Giovinco was unable to play in the MLS All-Star Game because of a heel injury, but he has a shot at getting back on the pitch for Toronto FC on Saturday.
The Sounders could be getting a number of players back from the Gold Cup this weekend, but Obafemi Martins remains sidelined with a groin injury.
Jozy Altidore has returned to Toronto FC after being dropped from the USMNT Gold Cup roster, but a number of key MLS players won't play this weekend.
RotoWire's JD Bazzo breaks down his top plays on DraftKings this weekend, including Kei Kamara, who is the cheapest of the three elite forwards on the Saturday slate.
With six goals in his last six matches, David Villa has been dominant for New York City FC, and he should only get better with the arrivals of Frank Lampard and Andrea Pirlo.