Chile can clinch the top spot in Group C with just a draw Monday, but Uruguay come in favored to win the clash of titans.
Friday's two-game slate has plenty of firepower, though fantasy players will be hard pressed to fade Neymar in cash games and GPPs.
Wednesday's slate includes multiple players with massive anytime goal scorer odds, so finding values to pair with players like Cristiano Ronaldo will be key.
Friday's three-game slate is highlighted by the big Spain v. Portugal match, but RotoWire's Andrew Laird explains why it might be a game to ignore for fantasy purposes.
Argentina has had a tough path to World Cup qualification, but there is a chance they could book their ticket to Russia if they beat Peru on Thursday and get help elsewhere.