Neymar has been dominant in Brazil's World Cup qualifiers this year, and he'll now face off against a Bolivia side that is the biggest underdog on Thursday's slate.
With Lionel Messi's status for this week still up in the air, finding the right alternatives will be the key to fantasy success.
The United States already clinched their spot in the semifinal, while six teams will compete for the last three spots over the next two days.
The group stage matches finish up Tuesday, but there is still plenty to be decided in Groups C and D, which should produce plenty of fantasy points.
Groups B and C will be decided Sunday and Monday, respectively, with plenty of fantasy points expected as teams go all-out to grab the final three points.
The Wednesday-Thursday slate is highlighted by Brazil, Uruguay and Mexico, with plenty of fantasy points to be had. JD Bazzo breaks down the top plays.