The Borussia Dortmund-Monaco matchup is expected to be high scoring, with Pierre-Emerick Aubameyang likely to contribute.
The Champions League quarterfinal matchups are stacked with high-end fantasy options, with Cristiano Ronaldo looking to make an impact against Bayern Munich in Germany.
Manchester United are heavy favorites over Sunderland on Sunday, even at the Stadium of Light, which means many fantasy managers will be looking toward Zlatan Ibrahimovic.
Sebastian Giovinco has struggled to get going this season, but he could finally break out Saturday against Atlanta United at home.
Manchester City are heavy favorites Saturday against Hull City at the Etihad, and getting exposure to their attack will be key.
After a disappointing midweek performance against Spurs, Kevin Swanson dives in to see if it's worth going back to Gylfi Sigurdsson.
Manchester City are the biggest favorites Saturday as they take on Hull City at the Etihad, and bookmakers are expecting a big game from Sergio Aguero.
Arsenal have been struggling of late, but Alexis Sanchez continues to be a very strong fantasy option.
James Milner's price is very high for a defender, but there are a few reasons why he should be in consideration Wednesday against Bournemouth.
Arsenal are heavy favorites over West Ham on Wednesday, which means plenty of fantasy managers will be focusing on Alexis Sanchez.
Idrissa Gueye has won the most tackles in the Premier League this season, and he figures to get plenty of opportunities for more Tuesday against Manchester United.
Jamie Vardy has found the back of the net four times in his last four league matches, and he'll look to add to his total Tuesday against Sunderland.
Zlatan Ibrahimovic returns after his four-match suspension, and he comes in with the best anytime goal scoring odds as Manchester United host Everton at Old Trafford.
With Lionel Messi suspended for Sunday's trip to Granada, Barcelona will have to rely more on Neymar, something that should surely peak the interest of fantasy managers.
Despite playing at the Emirates, Manchester City are favored over Arsenal, with Sergio Aguero coming in with the best anytime goal-scoring odds.
Minnesota United have allowed a boatload of goals this season, and with RSL next on the schedule, fantasy managers will certainly be looking toward Albert Rusnak.
With Paul Pogba and Zlatan Ibrahimovic out, Kevin Swanson is looking for Henrikh Mkhitaryan to make a big impact against West Brom.
Yannis Salibur has taken the second-most shots and sent in the most crosses among players in Friday's two-game slate.