Darrell Henderson finds himself back in the lead role with Cam Akers potentially done in Los Angeles, while Kenyan Drake could benefit in Baltimore if J.K. Dobbins has issues with his knee.
Chuba Hubbard didn't get many carries in Sunday's blowout loss, but it looks like he'll have a second run in the lead role with Christian McCaffrey ruled out for the season.
Dan Marcus goes deep into the free-agent pool to find upside adds who could pay off down the road, if not this week.
Josh Allen finally put it all together for the Bills in 2020 en route to a division title and appearance in the AFC Championship Game. They'll look to take the next step this season.
Josh Allen has been a fantasy star this season, and RotoWire's Andrew Laird is expecting him to be extremely popular on Monday night's slate.
Chase Edmonds supposedly was dealing with an ankle injury, yet finished Sunday's win over the Eagles with more carries, yards and snaps than Kenyan Drake.
Jerry Donabedian estimates Week 1 backfield usage for every team, expecting a large workload for James Conner and possibly a three-down role for Derrick Henry.