It might be now or never for DeAndre Hopkins, who catches the Colts battered and weak at cornerback.
Jaire Alexander might be able to contain Justin Jefferson, but the Packers might not have the luxury of matching them up.
Erik Siegrist previews the Monday night matchup with game predictions, fantasy projections and DFS picks as Ben Roethlisberger and the Steelers try to keep their playoff hopes alive against the Browns.
CeeDee Lamb should be in a bounce-back spot against an Arizona defense without its two lead outside corners.
Juan Carlos Blanco navigates a minefield of a Week 16 injury report that is loaded with big names for the second straight week at a critical juncture of the fantasy calendar.
Russell Gage's hot streak should continue against Detroit's battered secondary.
He mostly worked as a runner last week, but playing against Minnesota should get Deebo Samuel back on track as a pass catcher.
It's been a surprisingly quiet 2021 for Stefon Diggs, but that might change against the Jets in Week 10.
It's been an up-and-down season for the Philly passing game, but DeVonta Smith should swing back upward against Detroit.
The big play should show up soon for Jaylen Waddle -- perhaps Sunday against Atlanta's backup slot CB.
Odell Beckham might have some rust to shake off, but his matchup with the Vikings is perfect for a breakout.
The Vikings defense is begging to get burned deep Sunday, both by Tyler Lockett and DK Metcalf.
It could be a big day for Keenan Allen if Dallas matches up Trevon Diggs on Mike Williams.
The Colts could have a problem with DK Metcalf, especially if CB1 Xavier Rhodes (calf) can't play.
Allen Robinson didn't need any help, but the tanking Jaguars look poised to give it to him anyway as the Bears head to Jacksonville.
The Packers might not need him much to secure the victory, but if they look to Allen Lazard he will pose a big mismatch against Philadelphia's tiny corners.
After a two-week lull, Jamison Crowder might see his target volume spike upward against a Dolphins defense that's better outside than in the slot.
Ben Roethlisberger has been carrying Pittsburgh's offense without much help from the run game, and he should have another big day against an inexperienced Jaguars defense.