Manchester City are the biggest favorites on Saturday's seven-game slate, but stacking them might be tough on most sites because of their high salaries.
Paris Saint-Germain are huge favorites over Caen, which means plenty of fantasy players are likely to build their teams around Neymar.
Lorenzo Insigne could be a popular option on Tuesday's two-game slate, but he may not even start if Napoli rotate for their opening Coppa Italia match.
Andrew Laird and Jordan Cooper review their daily fantasy lineups from this past Saturday's Premier League slate, which were much different than expected once Willian started for Chelsea without Cesc Fabregas in the lineup.
Swansea City haven't won away from home since August, but they'll look for Jordan Ayew to help break the streak Monday at Everton.
Liverpool and Manchester United are both big favorites on Sunday's two-game slate, but fitting in all the high-powered stars will be tough to do in a single fantasy lineup.
Arsenal are big favorites at home against Newcastle on Saturday, which means fantasy players will be expecting a solid performance out of Alexis Sanchez.
Leroy Sane hasn't found the back of the net in quite a while, and while the matchup Saturday against Spurs isn't the easiest, City are still expected to be comfortably in control.
Xherdan Shaqiri is one of the most expensive midfielders on Saturday's six-game slate, but could fading him be too detrimental?
Chelsea are heavy favorites at home against Southampton on Saturday, and fantasy owners should turn their attention to defender Cesar Azpilicueta.
Andrew Laird and Mike Gottlieb preview the upcoming weekend of Premier League matches, including which player is the key to Tottenham competing with Manchester City, and whether Liverpool or Manchester United will win by bigger margins.
Hosting Tottenham is no small task, but RotoWire's Adam Zdroik still thinks that giving the FPL captain's armband to Kevin De Bruyne is a reasonable option.
Manchester City have a tough matchup at home against Tottenham on Saturday, but the oddsmakers still think Sergio Aguero has a good chance to find the back of the net.
Andrew Laird and Jordan Cooper review their midweek cash lineups on DraftKings before diving into a preview of Saturday's six-game Premier League slate, which could have many people focusing on Alexis Sanchez.
Alexandre Lacazette didn't start Arsenal's scoreless draw with West Ham on Wednesday, but he could lead the line Saturday at home against a struggling Newcastle.
Mohamed Salah and Philippe Coutinho get all the attention for those looking at Liverpool, but Roberto Firmino is in great form as well.
Sergio Aguero's price has dropped after two straight matches without a start, but he could be the best value on the board if he makes his way back in Wednesday.
Harry Kane was the chalk forward this past Saturday, and given his matchup at home against Brighton on Wednesday, we could be looking at more of the same.