Christian Benteke has been ruled out for the entire holiday period due to the knee injury he's been playing through over the past month.
Tim Howard has an excellent shot to take the league-lead in clean sheets on Boxing Day against Sunderland.
Sergio Aguero is expected to miss at least a month due to the calf injury he suffered in last weekend's tilt with Arsenal.
Theo Walcott is back to full fitness and coming off a brace last weekend against Manchester City, earning him a spot in this week's Best XI.
Fantasy owners spending big bucks on Mesut Ozil this week will need a few value players to keep their teams competitive.
Robin van Persie was a surprise member of Manchester United's starting XI last week, but suffered an injury in the Champions League on Tuesday and will now be out a month.
Arsenal paid a club-record amount to bring in Mesut Ozil for games such as this weekend's tilt against Manchester City.
If you're willing to shell out 10 percent of your salary cap on a guy like Sergio Aguero, finding value out of lower priced players is imperative.
With Robin van Persie out with injury and Wayne Rooney suspended this weekend, Nick Pitner names Danny Welbeck to his Best XI.
Robin van Persie has missed four games in a row and doesn't appear ready for this weekend's match against Newcastle.
Robin van Persie will likely be out again this weekend and Chris Mosinski has a great value player to fill his spot.
With his excellent play over the last month, Sergio Aguero moves up to the top of our striker rankings.
If you like Mesut Ozil for your squad this week, you'll need some value players to fill out the rest of your roster.
With matches on Tuesday and Wednesday this week before another weekend slate of matches, it's important to find players who likely won't sit despite the condensed schedule.
Vincent Kompany has been deemed fit and is expected to start Wednesday against West Brom.
Sergio Aguero has 16 goals and six assists in all competitions this season, making him an easy Best XI pick with a home match against Swansea on the schedule.
Robin van Persie's price continues to increase and with three gameweeks coming up within the next 10 days, the need for value players on your bench who can contribute when called upon is vital.
Vincent Kompany was held out of Manchester City's Champions League clash against Viktoria Plzen on Wednesday but looks set to return this weekend.