With Tottenham heavily favored at home against Fulham on Saturday, fantasy managers will have to decide whether it's optimal to choose one of Harry Kane or Christian Eriksen, or find enough value to roster both.
Tottenham are favored away to Newcastle on Saturday, and fantasy players could turn to Son Heung-Min before he leaves for the Asian Games.
Chelsea's Willian could be a popular cash-game target if he starts Saturday at Huddersfield, but RotoWire's Andrew Laird has a few other names worth considering for the five-game Premier League slate.
Chelsea are the biggest favorites on Saturday's five-game slate, with Alvaro Morata coming in with some of the best anytime goal scorer odds.
Harry Kane's quest for his third consecutive Golden Boot will likely have him firing plenty of shots Sunday at home against Leicester City.
Chelsea need a win at St. James' Park and help from Brighton to secure Champions League football for next season, which means they'll need a big performance from Eden Hazard.
Another season in the Champions League is in reach for Liverpool, and they'll likely rely on Mohamed Salah to get them there.
Potential rotation in the Chelsea lineup could throw a wrench in the plans of fantasy players, but Willian looks like a strong play away to Swansea if he can get the start.
Sunday's two-game FA Cup slate isn't expected to have a ton of goals, so fantasy players may have to rely on Willian for a lot of their points.
Bayern Munich lead Besiktas 5-0 on aggregate, but that doesn't make RotoWire's Schuyler Redpath hesitate on rostering James Rodriguez if he starts.
With few forwards to pay up for, Chelsea midfielder Eden Hazard could be the highest-owned player on Saturday's six-game slate.
Chelsea's attackers have been a bit inconsistent this season, but Willian may be too hard to pass up at home against Crystal Palace.
Bayern Munich are the biggest favorites on the four-game Champions League slate this week, and RotoWire's Schuyler Redpath explains why James Rodriguez should get plenty of fantasy attention.
Chelsea are the biggest favorites on Friday's four-game slate, which means fantasy players will likely be taking a long look at Eden Hazard.
Sergio Aguero doesn't come cheaply on Wednesday's seven-game slate, but RotoWire's Andrew Laird explains why it makes sense to pay up for the Man City striker.
Despite playing against Manchester United, RotoWire's Schuyler Redpath explains why Spurs fullback Kieran Trippier should get plenty of attention from fantasy players Wednesday.
Manchester City are once again big favorites with a high implied goal total, which means Kevin De Bruyne is likely to be a popular choice yet again.
With Leroy Sane sidelined with an ankle injury, Manchester City will look for Raheem Sterling to take on an even bigger attacking responsibility.