Many fantasy players will be drawn to Lionel Messi against Valencia on Thursday, but Barcelona aren't the biggest favorites on the two-game slate.
Napoli need a win and help elsewhere to qualify for the knockout rounds of the Champions League, and they'll look for Lorenzo Insigne to make a big impact.
Radamel Falcao has 11 goals in seven Ligue 1 matches this season, and he'll look to bag his first one in the Champions League Tuesday against Porto.