Andre-Pierre Gignac could be a popular play on Saturday's four-game Liga MX slate, though RotoWire's Andrew Laird sees some viable pivots for cash games and GPPs.
Belgium are big favorites against Japan on Monday, but fantasy players will have to decide who to fade if they also want a piece of Neymar.
Germany will look to bounce back from their opening loss when they take on Sweden, but fantasy players will likely be focusing on Belgium against Tunisia on Saturday.
Brazil are the biggest favorites on Sunday's three-game slates, but Germany's match against Mexico will certainly draw some eyeballs from fantasy players.
Germany, one of the favorites to win the World Cup, are expected to easily top Group F, but the battle for second place could be tight.
Lionel Messi headlines Saturday's four-game interleague slate, but a tough matchup at Sevilla doesn't make him as easy to play as usual.
After a disappointing 1-1 draw in Cyprus two weeks ago, Borussia Dortmund are expected to come out swinging at home against Apoel Nicosia on Wednesday.
Liverpool are big favorites at home against Maribor on Wednesday, and their attacking group is likely to get plenty of attention from fantasy players.
Despite possibly being without Philippe Coutinho, Liverpool are the biggest favorites on Wednesday's Champions League slate, and Mohamed Salah could have a major impact.
Monaco aren't the biggest favorites on Tuesday's eight-game Champions League slate, but bookmakers are still expecting Radamel Falcao to have a big impact.
The United States can book their ticket to Russia with a result at Trinidad & Tobago on Tuesday, and they come into the three-game slate as the heaviest favorites.
Radamel Falcao has 11 goals in seven Ligue 1 matches this season, and he'll look to bag his first one in the Champions League Tuesday against Porto.
Chile and Germany face off in the tournament final, but there could be plenty of fantasy points in the third-place game between Portugal and Mexico.
He has a tough matchup against a strong Chile side, but Evan Morter is still not likely to fade Cristiano Ronaldo on Wednesday.
With Portugal facing off against the worst team in their group, the sky's the limit for Cristiano Ronaldo.
Miguel Layun's role on set pieces makes him a very important part of the Mexico attack, and getting him as a defender is a big advantage for fantasy players.
Coming back from a two-goal deficit won't be easy, but if Monaco are to do it, Radamel Falcao will likely be involved.
Juventus come in as the biggest favorite on Tuesday's two-game slate, with fantasy owners likely turning their attention toward Paulo Dybala.