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Perez was lifted from his start Wednesday against the Orioles in the top of the fourth inning due to left shoulder soreness. He was charged with three earned runs on five hits and two walks while striking out two batters before exiting.
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The Royals optioned Avila to Triple-A Omaha on Wednesday.
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The Royals activated Ragans (shoulder) from the 60-day injured list Wednesday.
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The Nationals recalled Lao from Triple-A Rochester on Wednesday.
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The Nationals optioned Ribalta to Triple-A Rochester on Wednesday.
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Red Sox manager Alex Cora said that Early will start Sunday's series finale in Tampa against the Rays, Tim Healey of The Boston Globe reports.
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Diamondbacks manager Torey Lovullo said Wednesday that Crismatt will be moved to the bullpen while Arizona proceeds with a four-man rotation for the rest of the season, Alex D'Agostino of SI.com reports.
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Musgrove (elbow) threw an "up-down" bullpen session at Citi Field on Tuesday, Kevin Acee of The San Diego Union-Tribune reports.
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Cortes (biceps) is scheduled to face live hitters Friday at the Padres' facility in Arizona, Kevin Acee of The San Diego Union-Tribune reports.
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White Sox general manager Chris Getz said Wednesday that he expects Vasil to remain in the bullpen next season, Scott Merkin of MLB.com reports.
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The Rays selected Wilcox's contract from Triple-A Durham on Wednesday.
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The Rays optioned Gerber to Triple-A Durham on Wednesday, Ryan Bass of FanDuel Sports Network Sun reports.
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Rogers (toe) will start Friday's game against the Yankees at Camden Yards, Roch Kubatko of MASNSports.com reports.
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The Pirates optioned Sanders to Triple-A Indianapolis on Wednesday, Colin Beazley of the Pittsburgh Post-Gazette reports.
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The Pirates reinstated Ramirez (personal) from the paternity list Wednesday, Colin Beazley of the Pittsburgh Post-Gazette reports.
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Skenes (10-10) took the loss Tuesday, giving up three runs on seven hits and three walks over 3.2 innings as the Pirates were downed 4-1 by the Cubs. He struck out six.
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Kittredge worked a scoreless inning of relief with two strikeouts in Tuesday's 4-1 win over the Pirates, though it was Brad Keller who got the ninth and the save.
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Smith (7-5) blew the save but picked up the win Tuesday, striking out two and giving up a solo home run in the ninth inning of a 7-5 extra-inning victory over the Tigers.
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Horton (11-4) allowed just one run on three hits across five innings to earn the win in Tuesday's 4-1 victory over the Pirates. He walked one and struck out six.
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Cantillo didn't factor into the decision in Tuesday's 7-5 extra-inning win over the Tigers, allowing one run on four hits and two walks over five innings. He struck out three.
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Gore came away with a no-decision in the second game of Tuesday's doubleheader against Atlanta, allowing two hits and three walks over 5.1 scoreless innings. He struck out five.
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Irvin (8-13) took the loss in the first game of Tuesday's doubleheader against Atlanta, coughing up five runs on eight hits and two walks over six innings. He struck out five.
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Harris had a scoreless appearance while allowing one hit over an inning and a third to pick up the save over the Red Sox on Tuesday. He did not strike out or walk a batter in the process.
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Keller tossed a scoreless ninth inning with two strikeouts to earn the save in Tuesday's 4-1 win over the Pirates.
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Sale came away with a no-decision in the second game of Tuesday's doubleheader against the Nationals, scattering three hits over eight scoreless innings. He struck out nine without walking a batter.
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