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Pena went 3-for-5 with a solo home run and an additional run scored in Wednesday's 7-4 loss to the Tigers.
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Blubaugh (0-1) was charged with the loss Wednesday against the Tigers after giving up seven runs (two earned) on five hits and a walk over four innings. He struck out six.
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Wesneski isn't expected to make his next start until the Astros' three-game series in Milwaukee early next week, Brian McTaggart of MLB.com reports.
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McCullers (forearm) will return from the 15-day injured list Sunday and will start in the Astros' series finale against the White Sox in Chicago, Matt Kawahara of the Houston Chronicle reports.
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Dubon is out of the lineup for Wednesday's game against the Tigers, Matt Kawahara of the Houston Chronicle reports.
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Diaz is not in the lineup for Wednesday's game against the Tigers.
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Alvarez is absent from the lineup for Wednesday's game against the Tigers.
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The Astros selected Blubaugh's contract from Triple-A Sugar Land ahead of his scheduled start Wednesday against the Tigers in Houston.
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The Astros placed Abreu on the paternity list Wednesday.
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Hader allowed two earned runs on two hits and no walks while striking out one across one inning Tuesday against the Tigers.
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Paredes went 1-for-2 with a triple, two walks, an RBI and two runs scored Tuesday against the Tigers.
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Diaz went 2-for-4 with three RBI in Tuesday's win over Detroit.
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Blubaugh will start Wednesday's game against the Tigers, Chandler Rome of The Athletic reports.
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Gusto didn't factor into the decision Tuesday against the Tigers after allowing two runs on four hits and two walks in 4.1 innings. He struck out six.
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Manager Joe Espada said McCullers (forearm) will throw a bullpen session Wednesday before the Astros determine whether he's ready to be reinstated from the injured list, Brian McTaggart of MLB.com reports.
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Blubaugh is with the Astros as a member of the taxi squad and is a candidate to start Wednesday against the Tigers, Matt Kawahara of the Houston Chronicle reports.
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Manager Joe Espada said Tuesday that Wesneski is healthy but won't make his scheduled turn through the rotation Wednesday against the Tigers in order to get him some extra rest, Chandler Rome of The Athletic reports.
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Alvarez (undisclosed) will start at designated hitter and bat third in Tuesday's game versus the Tigers.
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Smith is absent from the lineup for Tuesday's contest against the Tigers.
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Dubon went 1-for-4 with two RBI and a run scored Monday against the Tigers.
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Pena went 2-for-4 with a double and two runs scored Monday against the Tigers.
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Walker went 1-for-4 with a two-run home run in an 8-5 win against the Tigers on Monday.
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Altuve went 2-for-4 with a home run and three total RBI in Monday's 8-5 victory versus Detroit.
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Hader earned a save against the Tigers on Monday, allowing one hit and striking out two batters in a scoreless inning of work.
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Blanco allowed three runs on three hits and two walks while striking out six batters over five innings in a no-decision against Detroit on Monday.
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