Mitch Trubisky can miss the wide side of a barn, but Chase Claypool could do damage anyway against New England's tiny and slow slot corner.
The Bears struggled against Justin Jefferson the first time around, and they might have a rough go of it again potentially down two of their top three cornerbacks Sunday.
Beast or not, DeAndre Hopkins might have some trouble against James Bradberry, especially as defenses increasingly catch on to Arizona's static route combinations.
The Packers might not need him much to secure the victory, but if they look to Allen Lazard he will pose a big mismatch against Philadelphia's tiny corners.
Jerry Donabedian sees a lot of good chalk on the board in Week 6, including Ryan Tannehill and A.J. Brown in a home game against the Texans.
A matchup with the Jets is the primary basis for this week's No. 1 streaming pick, but it doesn't hurt that the Dolphins have actually looked pretty good, led by three interceptions from CB Xavien Howard.
Will Fuller's breakout season may yet resume, but a matchup with the Baltimore corner rotation is a good way to briefly derail it.
T.Y. Hilton was a disappointment in Jacksonville last week, but he should fare much better playing indoors against a burnable Minnesota secondary.
Erik Siegrist previews the Monday night matchup as the Raiders christen their Las Vegas home against the Saints.
No matter whether he runs more from the slot or out wide, it's difficult to see what the Raiders corners can do to slow down D.J. Moore.
Jason Garrett drew ridicule as the head coach of the Cowboys, but his background as a quarterbacks coach could be beneficial for Daniel Jones with the Giants.
AJ Brown and the Titans need to win, and the Texans don't have much reason to put up a fight.
With Tampa Bay's top corner questionable with an ankle issue, DeAndre Hopkins is in position to deliver for his owners in Championship Week.
The 49ers passing game finally came to life against the Saints, and Emmanuel Sanders and company get another nice matchup against a Falcons defense without Desmond Trufant.
The Steelers found success moving James Washington to the slot in Week 13, and he's poised for another strong game against a limping Arizona cornerback rotation in Week 14.
Jerry Donabedian looks at the key matchups for Week 13, explaining why Jack Doyle is underrated and pecan pie is overrated.
The Jets secondary is weak where Tyrell Williams runs his routes, positioning the Raiders wideout to go over 100 yards for the first time since Week 1.
With projected matchups against two rookie corners as Nick Foles returns to the field, it may be time for D.J. Chark to return to the spotlight.