After trading Deshaun Watson to the Browns, the Texans will turn to second-year signal-caller Davis Mills to helm the offense of a franchise in transition.
Latavius Murray made his first start for the Ravens in Week 4 and hit paydirt for a third time in four games.
The Steelers haven't shown much of a running game through two weeks, but Najee Harris should get enough to flirt with RB1 status anyway.
Paced by lead running back Nick Chubb and other name skill-position players, the Browns will aim for back-to-back playoff appearances for the first time in 2021 since the team had five such berths from 1985-89.
The Eagles and Texans aren't looking so hot, but their Week 2 backfield distribution was highly promising for anyone who invested in Miles Sanders or David Johnson.
Jerry Donabedian estimates Week 1 backfield usage for every team, expecting a large workload for James Conner and possibly a three-down role for Derrick Henry.
Kareem Hunt has mammoth upside in the event of a Nick Chubb injury, but Hunt's current ADP also creates a lot of bust potential.
Jerry Donabedian breaks down some of the backfields that experienced offseason turmoil, starting with both Los Angeles teams.
If quarterback Baker Mayfield can turn things around, the Browns could contend for a playoff spot in 2020. Until further notice, though, the Ravens are the class of the AFC North.
Tee Higgins might have been a first-round pick in other years, but tough competition in a deep WR class could push him down to the second round as an unexpected gift for the Ravens or Texans.
Jerry Donabedian breaks down every game from Week 9, noting how new Chargers offensive coordinator Shane Steichen put Melvin Gordon in good position for his first big game of the season.